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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2007-7-27
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pubmed:abstractText |
The opening of the mitochondrial permeability transition pore (mPTP) at the time of myocardial reperfusion is a critical determinant of cell death. Emerging studies suggest that suppression of mPTP opening may underlie the cardioprotection elicited by both ischemic preconditioning (IPC) and postconditioning (IPost). To further evaluate the role of the mPTP in cardioprotection, we hypothesized that hearts deficient in cyclophilin-D (CYP-D-/-), a key component of the mPTP, will be resistant to cardioprotection conferred by ischemic and pharmacological preconditioning and postconditioning.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17512507-12692185,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17512507-12860564,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17512507-14659807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17512507-14749836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17512507-15066952,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17512507-15072953,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17512507-15173880,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17512507-15642769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17512507-15792954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17512507-15800626,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17512507-15800627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17512507-16103352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17512507-16186417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17512507-16216231,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17512507-16280253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17512507-16720572,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17512507-3117053,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17512507-3196322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17512507-3769170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17512507-7717999
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bradykinin,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclophilins,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclosporine,
http://linkedlifedata.com/resource/pubmed/chemical/Diazoxide,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Lactones,
http://linkedlifedata.com/resource/pubmed/chemical/Mitochondrial Membrane Transport...,
http://linkedlifedata.com/resource/pubmed/chemical/Spiro Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Vasodilator Agents,
http://linkedlifedata.com/resource/pubmed/chemical/cyclophilin D,
http://linkedlifedata.com/resource/pubmed/chemical/mitochondrial permeability...,
http://linkedlifedata.com/resource/pubmed/chemical/sanglifehrin A
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0008-6363
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
75
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
530-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17512507-Animals,
pubmed-meshheading:17512507-Bradykinin,
pubmed-meshheading:17512507-Cyclophilins,
pubmed-meshheading:17512507-Cyclosporine,
pubmed-meshheading:17512507-Diazoxide,
pubmed-meshheading:17512507-Enzyme Inhibitors,
pubmed-meshheading:17512507-Female,
pubmed-meshheading:17512507-Ischemic Preconditioning, Myocardial,
pubmed-meshheading:17512507-Lactones,
pubmed-meshheading:17512507-Male,
pubmed-meshheading:17512507-Mice,
pubmed-meshheading:17512507-Mice, Knockout,
pubmed-meshheading:17512507-Mitochondria, Heart,
pubmed-meshheading:17512507-Mitochondrial Membrane Transport Proteins,
pubmed-meshheading:17512507-Models, Animal,
pubmed-meshheading:17512507-Myocardial Ischemia,
pubmed-meshheading:17512507-Myocardial Reperfusion Injury,
pubmed-meshheading:17512507-Myocardium,
pubmed-meshheading:17512507-Spiro Compounds,
pubmed-meshheading:17512507-Vasodilator Agents
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pubmed:year |
2007
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pubmed:articleTitle |
Preconditioning and postconditioning: the essential role of the mitochondrial permeability transition pore.
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pubmed:affiliation |
The Hatter Cardiovascular Institute, University College London Hospital and Medical School, 67 Chenies Mews, London WC1E 6HX, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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