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rdf:type |
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lifeskim:mentions |
umls-concept:C0026336,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0038435,
umls-concept:C0205191,
umls-concept:C0441655,
umls-concept:C0531004,
umls-concept:C0547040,
umls-concept:C1569108,
umls-concept:C1657294,
umls-concept:C1961132
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pubmed:issue |
10
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pubmed:dateCreated |
2007-11-6
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pubmed:abstractText |
The endocannabinoid anandamide may be involved in the regulation of emotional reactivity. In particular, it has been shown that pharmacological inhibition of the enzyme fatty acid amide hydrolase (FAAH), which catalyzes the intracellular hydrolysis of anandamide, elicits anxiolytic-like and antidepressant-like effects in rodents.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amidohydrolases,
http://linkedlifedata.com/resource/pubmed/chemical/Antidepressive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Benzamides,
http://linkedlifedata.com/resource/pubmed/chemical/Carbamates,
http://linkedlifedata.com/resource/pubmed/chemical/Endocannabinoids,
http://linkedlifedata.com/resource/pubmed/chemical/Imipramine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Cannabinoid, CB1,
http://linkedlifedata.com/resource/pubmed/chemical/Sucrose,
http://linkedlifedata.com/resource/pubmed/chemical/cyclohexyl carbamic acid...,
http://linkedlifedata.com/resource/pubmed/chemical/fatty-acid amide hydrolase
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0006-3223
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
62
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1103-10
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pubmed:meshHeading |
pubmed-meshheading:17511970-Amidohydrolases,
pubmed-meshheading:17511970-Animals,
pubmed-meshheading:17511970-Antidepressive Agents,
pubmed-meshheading:17511970-Behavior, Animal,
pubmed-meshheading:17511970-Benzamides,
pubmed-meshheading:17511970-Body Weight,
pubmed-meshheading:17511970-Brain,
pubmed-meshheading:17511970-Carbamates,
pubmed-meshheading:17511970-Chronic Disease,
pubmed-meshheading:17511970-Disease Models, Animal,
pubmed-meshheading:17511970-Dose-Response Relationship, Drug,
pubmed-meshheading:17511970-Endocannabinoids,
pubmed-meshheading:17511970-Gene Expression Regulation,
pubmed-meshheading:17511970-Imipramine,
pubmed-meshheading:17511970-Lipid Metabolism,
pubmed-meshheading:17511970-Male,
pubmed-meshheading:17511970-Multivariate Analysis,
pubmed-meshheading:17511970-Rats,
pubmed-meshheading:17511970-Rats, Wistar,
pubmed-meshheading:17511970-Receptor, Cannabinoid, CB1,
pubmed-meshheading:17511970-Stress, Psychological,
pubmed-meshheading:17511970-Sucrose,
pubmed-meshheading:17511970-Time Factors
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pubmed:year |
2007
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pubmed:articleTitle |
Antidepressant-like activity of the fatty acid amide hydrolase inhibitor URB597 in a rat model of chronic mild stress.
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pubmed:affiliation |
Department of Pharmacology, University of California, Irvine, California 92697-4260, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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