Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2007-5-18
pubmed:abstractText
Common Variable Immunodeficiency belongs to the group of rare diseases encompassing antibody deficiency syndromes of highly variable clinical presentation and outcome. The multicenter prospective study on a cohort of 224 patients with Common Variable Immunodeficiency provides an updated view of the spectrum of illnesses which occurred at the clinical onset and over a long period of follow-up (mean time: 11 years) and information on the effects of long-term immunoglobulin treatment. The mean age at the time of diagnosis was 26.6 years. Seventy-five patients were younger than 14 years of age. The mean age at the onset of symptoms was 16.9 years. This implicates with a mean diagnostic delay of 8.9 years. Respiratory tract infections were the most prominent clinical problem observed at diagnosis and during the follow-up. Intravenous immunoglobulin administration induced a significant reduction in the incidence of acute infections, mainly acute pneumonia and acute otitis. However, a progressive increase in the prevalence of patients with chronic diseases, mainly sinusitis and lung disease, was observed in all age groups, including the pediatric population. The morbidity of Common Variable Immunodeficiency due to all associated clinical conditions increased over time despite an adequate replacement with intravenous immunoglobulins. Our data stressed the need to develop international guidelines for the prevention and therapy of chronic lung disease, chronic sinusitis, chronic diarrhoea, and chronic granulomatosis in patients with humoral immunodeficiencies.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0271-9142
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
308-16
pubmed:meshHeading
pubmed-meshheading:17510807-Adolescent, pubmed-meshheading:17510807-Adult, pubmed-meshheading:17510807-Age Distribution, pubmed-meshheading:17510807-Aged, pubmed-meshheading:17510807-Autoimmune Diseases, pubmed-meshheading:17510807-Child, pubmed-meshheading:17510807-Child, Preschool, pubmed-meshheading:17510807-Cohort Studies, pubmed-meshheading:17510807-Common Variable Immunodeficiency, pubmed-meshheading:17510807-Female, pubmed-meshheading:17510807-Follow-Up Studies, pubmed-meshheading:17510807-Humans, pubmed-meshheading:17510807-Immunoglobulins, pubmed-meshheading:17510807-Immunotherapy, pubmed-meshheading:17510807-Male, pubmed-meshheading:17510807-Middle Aged, pubmed-meshheading:17510807-Neoplasms, pubmed-meshheading:17510807-Survival Rate, pubmed-meshheading:17510807-Time Factors, pubmed-meshheading:17510807-Treatment Outcome
pubmed:year
2007
pubmed:articleTitle
Long-term follow-up and outcome of a large cohort of patients with common variable immunodeficiency.
pubmed:affiliation
Department of Clinical Immunology, University of Rome La Sapienza Rome, Rome, Italy. isabella.quinti@uniroma1.it
pubmed:publicationType
Journal Article, Multicenter Study