Linked Life Data

17510236

Source:http://linkedlifedata.com/resource/pubmed/id/17510236

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2007-7-19
pubmed:abstractText
The identification of molecular differences in the endometrium of women with endometriosis is an important step toward understanding the pathogenesis of this condition and toward developing novel strategies for the treatment of associated infertility and pain. In this study, we conducted global gene expression analysis of endometrium from women with and without moderate/severe stage endometriosis and compared the gene expression signatures across various phases of the menstrual cycle. The transcriptome analysis revealed molecular dysregulation of the proliferative-to-secretory transition in endometrium of women with endometriosis. Paralleled gene expression analysis of endometrial specimens obtained during the early secretory phase demonstrated a signature of enhanced cellular survival and persistent expression of genes involved in DNA synthesis and cellular mitosis in the setting of endometriosis. Comparative gene expression analysis of progesterone-regulated genes in secretory phase endometrium confirmed the observation of attenuated progesterone response. Additionally, interesting candidate susceptibility genes were identified that may be associated with this disorder, including FOXO1A, MIG6, and CYP26A1. Collectively these findings provide a framework for further investigations on causality and mechanisms underlying attenuated progesterone response in endometrium of women with endometriosis.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0013-7227
pubmed:author
pubmed:issnType
Print
pubmed:volume
148
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3814-26
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:17510236-Adaptor Proteins, Signal Transducing, pubmed-meshheading:17510236-Adult, pubmed-meshheading:17510236-Cytochrome P-450 Enzyme System, pubmed-meshheading:17510236-Endometriosis, pubmed-meshheading:17510236-Endometrium, pubmed-meshheading:17510236-Female, pubmed-meshheading:17510236-Forkhead Transcription Factors, pubmed-meshheading:17510236-Gene Expression Profiling, pubmed-meshheading:17510236-Genetic Linkage, pubmed-meshheading:17510236-Genetic Predisposition to Disease, pubmed-meshheading:17510236-Humans, pubmed-meshheading:17510236-Leiomyoma, pubmed-meshheading:17510236-Oligonucleotide Array Sequence Analysis, pubmed-meshheading:17510236-Progesterone, pubmed-meshheading:17510236-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:17510236-Tumor Suppressor Proteins, pubmed-meshheading:17510236-Uterine Neoplasms
pubmed:year
2007
pubmed:articleTitle
Gene expression analysis of endometrium reveals progesterone resistance and candidate susceptibility genes in women with endometriosis.
pubmed:affiliation
Department of Obstetrics and Gynecology, Stanford University, Stanford, California 94305, USA.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural