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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2007-5-18
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pubmed:abstractText |
The N-acetyltransferase 2 (NAT2) enzyme detoxifies aromatic amines, an important class of carcinogens in tobacco smoke. Slow acetylation phenotype individuals have reduced detoxification capacity compared with those with a rapid/intermediate phenotype. Analysis of the Spanish Bladder Cancer Study found an odds ratio (OR) for slow acetylators relative to rapid/intermediate acetylators of 0.9 in never-smokers and 1.6 in ever-smokers, a 1.8-fold enhancement in smokers. Evidence indicates that acetylation is an exposure-dependent process, and thus the magnitude of the interaction may also depend on exposure level.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0300-5771
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pubmed:author |
pubmed-author:CarratoAlfredoA,
pubmed-author:DosemeciMustafaM,
pubmed-author:Garcia-ClosasMontserratM,
pubmed-author:Garcia-ClosasReinaR,
pubmed-author:HeinDavid WDW,
pubmed-author:KogevinasManolisM,
pubmed-author:MEEKE EEE,
pubmed-author:MalatsNúriaN,
pubmed-author:RothmanNathanielN,
pubmed-author:SerraConsolC,
pubmed-author:SilvermanDebraD,
pubmed-author:TardónAdoninaA
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pubmed:issnType |
Print
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
236-41
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pubmed:dateRevised |
2010-9-8
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pubmed:meshHeading |
pubmed-meshheading:17510079-Acetylation,
pubmed-meshheading:17510079-Adult,
pubmed-meshheading:17510079-Aged,
pubmed-meshheading:17510079-Aged, 80 and over,
pubmed-meshheading:17510079-Arylamine N-Acetyltransferase,
pubmed-meshheading:17510079-Genotype,
pubmed-meshheading:17510079-Humans,
pubmed-meshheading:17510079-Linear Models,
pubmed-meshheading:17510079-Middle Aged,
pubmed-meshheading:17510079-Phenotype,
pubmed-meshheading:17510079-Risk Assessment,
pubmed-meshheading:17510079-Smoking,
pubmed-meshheading:17510079-Spain,
pubmed-meshheading:17510079-Tobacco,
pubmed-meshheading:17510079-Tobacco Smoke Pollution,
pubmed-meshheading:17510079-Urinary Bladder Neoplasms
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pubmed:year |
2007
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pubmed:articleTitle |
Evidence for an intensity-dependent interaction of NAT2 acetylation genotype and cigarette smoking in the Spanish Bladder Cancer Study.
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pubmed:affiliation |
Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd., Rockville, MD 20852, USA. lubinj@mail.nih.gov
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Intramural
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