Source:http://linkedlifedata.com/resource/pubmed/id/17509088
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2007-7-31
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| pubmed:abstractText |
We recently demonstrated that dopaminergic (DA) neurons of the rat substantia nigra constitutively expressed CXCR4, receptor for the chemokine stromal cell-derived factor-1 (SDF-1)/CXCL12 (SDF-1). To check the physiological relevance of such anatomical observation, in vitro and in vivo approaches were used. Patch clamp recording of DA neurons in rat substantia nigra slices revealed that SDF-1 (10 nmol/L) induced: (i) a depolarization and increased action potential frequency; and (ii) switched the firing pattern of depolarized DA neurons from a tonic to a burst firing mode. This suggests that SDF-1 could increase DA release from neurons. Consistent with this hypothesis, unilateral intranigral injection of SDF-1 (50 ng) in freely moving rat decreased DA content and increased extracellular concentrations of DA and metabolites in the ipsilateral dorsal striatum, as shown using microdialysis. Furthermore, intranigral SDF-1 injection induced a contralateral circling behavior. These effects of SDF-1 were mediated via CXCR4 as they were abrogated by administration of a selective CXCR4 antagonist. Altogether, these data demonstrate that SDF-1, via CXCR4, activates nigrostriatal DA transmission. They show that the central functions of chemokines are not restricted, as originally thought, to neuroinflammation, but extend to neuromodulatory actions on well-defined neuronal circuits in non-pathological conditions.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Ccr4 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CXCL12,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, CXC,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR4,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Chemokine,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine 3-Monooxygenase
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| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
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| pubmed:issn |
0022-3042
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
102
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1175-83
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:17509088-Action Potentials,
pubmed-meshheading:17509088-Animals,
pubmed-meshheading:17509088-Behavior, Animal,
pubmed-meshheading:17509088-Brain Chemistry,
pubmed-meshheading:17509088-Chemokine CXCL12,
pubmed-meshheading:17509088-Chemokines, CXC,
pubmed-meshheading:17509088-Corpus Striatum,
pubmed-meshheading:17509088-Dopamine,
pubmed-meshheading:17509088-Dose-Response Relationship, Drug,
pubmed-meshheading:17509088-Functional Laterality,
pubmed-meshheading:17509088-Male,
pubmed-meshheading:17509088-Microdialysis,
pubmed-meshheading:17509088-Motor Activity,
pubmed-meshheading:17509088-Rats,
pubmed-meshheading:17509088-Rats, Wistar,
pubmed-meshheading:17509088-Receptors, CCR4,
pubmed-meshheading:17509088-Receptors, Chemokine,
pubmed-meshheading:17509088-Substantia Nigra,
pubmed-meshheading:17509088-Tyrosine 3-Monooxygenase
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| pubmed:year |
2007
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| pubmed:articleTitle |
The chemokine stromal cell-derived factor-1/CXCL12 activates the nigrostriatal dopamine system.
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| pubmed:affiliation |
Institut National de la Santé et de la Recherche Médicale (INSERM) U 732, Université Pierre et Marie Curie-Paris 6, Hôpital Saint-Antoine, Paris Cedex, France.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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