Source:http://linkedlifedata.com/resource/pubmed/id/17508776
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2007-5-18
|
| pubmed:abstractText |
We describe the packing features of the oligonucleotide duplex d(AAATTT)2, as determined by X-ray diffraction. There is little information on sequences that only contain A and T bases. The present structure confirms that these sequences tend to pack as a helical arrangement of stacked oligonucleotides in a B conformation with Watson-Crick hydrogen bonding. Our results demonstrate that the virtual TA base step between stacked duplexes has a negative twist that improves base stacking. This observation is consistent with the low stability of TA base steps in B-form DNA.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0739-1102
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
24
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
547-52
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| pubmed:meshHeading |
pubmed-meshheading:17508776-Adenine,
pubmed-meshheading:17508776-Base Sequence,
pubmed-meshheading:17508776-Models, Molecular,
pubmed-meshheading:17508776-Nucleic Acid Conformation,
pubmed-meshheading:17508776-Oligodeoxyribonucleotides,
pubmed-meshheading:17508776-Thymine,
pubmed-meshheading:17508776-X-Ray Diffraction
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
Packing features of the all-AT oligonucleotide d(AAATTT).
|
| pubmed:affiliation |
Departament d'Enginyeria Quimica, Universitat Politecnica de Catalunya, Av. Diagonal 647, E-08028 Barcelona, Spain.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|