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rdf:type |
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lifeskim:mentions |
umls-concept:C0003316,
umls-concept:C0019704,
umls-concept:C0019737,
umls-concept:C0021311,
umls-concept:C0026882,
umls-concept:C0205191,
umls-concept:C0205421,
umls-concept:C0328767,
umls-concept:C0870509,
umls-concept:C1415561,
umls-concept:C1456706
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pubmed:issue |
15
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pubmed:dateCreated |
2007-7-12
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pubmed:abstractText |
HLA-B*5703 is associated with effective immune control in human immunodeficiency virus type 1 (HIV-1) infection. Here we describe an escape mutation within the immunodominant HLA-B*5703-restricted epitope in chronic HIV-1 infection, KAFSPEVIPMF (Gag 162-172), and demonstrate that this mutation reduces viral replicative capacity. Reversion of this mutation following transmission to HLA-B*5703-negative recipients was delayed by the compensatory mutation S165N within the same epitope. These data may help explain the observed association between HLA-B*5703 and long-term control of viremia.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17507468-10449480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17507468-11148222,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17507468-11836408,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17507468-12029119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17507468-12134033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17507468-14530136,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17507468-14685052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17507468-14770175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17507468-14966520,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17507468-15067030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17507468-15210746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17507468-15286729,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17507468-15592417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17507468-15781581,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17507468-15827187,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17507468-16103206,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17507468-16140787,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17507468-16439520,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17507468-16519915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17507468-16537629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17507468-16690137,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17507468-16731944,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17507468-17065207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17507468-17121793,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17507468-17173051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17507468-17182686,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17507468-17251285,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17507468-17251297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17507468-17330784,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17507468-7492437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17507468-7699324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17507468-8597949,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17507468-9516110
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-538X
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pubmed:author |
pubmed-author:AllenSusanS,
pubmed-author:BranderChristianC,
pubmed-author:CrawfordHayleyH,
pubmed-author:GoepfertPaulP,
pubmed-author:GoulderPhilip J RPJ,
pubmed-author:HoneyborneIsobellaI,
pubmed-author:HuéStéphaneS,
pubmed-author:HunterEricE,
pubmed-author:KaslowRichardR,
pubmed-author:KiepielaPhotiniP,
pubmed-author:LeslieAlasdairA,
pubmed-author:MncubeZeneleZ,
pubmed-author:MulengaJosephJ,
pubmed-author:MullinsJames IJI,
pubmed-author:PradoJulia GJG,
pubmed-author:ReddySharonS,
pubmed-author:RousseauChristineC,
pubmed-author:WalkerBruce DBD,
pubmed-author:van der StokMaryM
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pubmed:issnType |
Print
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pubmed:volume |
81
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
8346-51
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pubmed:dateRevised |
2010-12-17
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pubmed:meshHeading |
pubmed-meshheading:17507468-Amino Acid Sequence,
pubmed-meshheading:17507468-Gene Products, gag,
pubmed-meshheading:17507468-HIV Infections,
pubmed-meshheading:17507468-HIV-1,
pubmed-meshheading:17507468-HLA-B Antigens,
pubmed-meshheading:17507468-Humans,
pubmed-meshheading:17507468-Immunodominant Epitopes,
pubmed-meshheading:17507468-Likelihood Functions,
pubmed-meshheading:17507468-Mutation,
pubmed-meshheading:17507468-Phylogeny,
pubmed-meshheading:17507468-Virus Replication
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pubmed:year |
2007
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pubmed:articleTitle |
Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection.
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pubmed:affiliation |
Department of Pediatrics, University of Oxford, Peter Medawar Building for Pathogen Research, South Parks Rd., Oxford OX1 3SY, United Kingdom.
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