Linked Life Data

17507221

Source:http://linkedlifedata.com/resource/pubmed/id/17507221

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
14
pubmed:dateCreated
2007-6-22
pubmed:abstractText
A novel class of non-peptide somatostatin receptor ligands bearing the octahydrobenzo[g]quinoline (obeline) structural element has been identified. SAR studies have been performed that led to the discovery of derivatives with high affinity (pK(d) r sst(1) > or = 9) and selectivity (> or = 150-fold for h sst(1) over h sst(2)-h sst(5)) for somatostatin receptor subtype sst(1). In a functional assay, the compounds act as antagonists at human recombinant sst(1) receptors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0960-894X
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3983-7
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Identification and SAR of potent and selective non-peptide obeline somatostatin sst1 receptor antagonists.
pubmed:affiliation
Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland. thomas.troxler@novartis.com
pubmed:publicationType
Journal Article