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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2007-5-29
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pubmed:abstractText |
Epstein-Barr virus-induced gene (EBI)-3 codes for a soluble type 1 cytokine receptor homologous to the p40 subunit of IL-12 that is expressed by antigen-presenting cells following activation. Here, we analyzed the functional role of EBI-3 in a murine model of asthma associated with airway hyper-responsiveness (AHR) in ovalbumin-sensitized mice. Upon allergen challenge, EBI-3-/- mice showed less severe AHR, decreased numbers and degranulation of eosinophils and a significantly reduced number of VCAM-1+ cells in the lungs as compared to wild-type littermates. We thus analyzed lung CD11c+ cells before and after allergen challenge in these mice and found that before allergen challenge, lung CD11c+ cells isolated from EBI-3-/- mice express markers of a more plasmacytoid phenotype without releasing IFN-alpha as compared to those from wild-type littermates. Moreover, allergen challenge induced the development of myeloid CD11c+ cells in the lungs of EBI-3-/- mice, which released increased amounts of IL-10 and IL-12 while not expressing IFN-alpha. Finally, inhibition of EBI-3 expression in lung DC could prevent AHR in adoptive transfer studies by suppressing mediator release of effector cells into the airways. These results indicate a novel role for EBI-3 in controlling local immune responses in the lungs in experimental asthma.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD11c,
http://linkedlifedata.com/resource/pubmed/chemical/Ebi3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-10,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-12,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-5,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytokine,
http://linkedlifedata.com/resource/pubmed/chemical/STAT4 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Stat4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/T-Box Domain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/T-box transcription factor TBX21,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Cell Adhesion Molecule-1
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0014-2980
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pubmed:author |
pubmed-author:BirkenbachMarkM,
pubmed-author:BlumbergRichard SRS,
pubmed-author:FinottoSusettaS,
pubmed-author:GallePeter RPR,
pubmed-author:HausdingMichaelM,
pubmed-author:KarwotRomanR,
pubmed-author:LehrHans AHA,
pubmed-author:NeurathMarkus FMF,
pubmed-author:RenzHaraldH,
pubmed-author:ScholtesPetraP,
pubmed-author:WegmannMichaelM
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pubmed:issnType |
Print
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1663-77
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17506035-Animals,
pubmed-meshheading:17506035-Antigens, CD11c,
pubmed-meshheading:17506035-Asthma,
pubmed-meshheading:17506035-Bronchial Hyperreactivity,
pubmed-meshheading:17506035-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:17506035-CD8-Positive T-Lymphocytes,
pubmed-meshheading:17506035-Cell Proliferation,
pubmed-meshheading:17506035-Cell Transplantation,
pubmed-meshheading:17506035-Dendritic Cells,
pubmed-meshheading:17506035-Eosinophils,
pubmed-meshheading:17506035-Interferon-alpha,
pubmed-meshheading:17506035-Interferon-gamma,
pubmed-meshheading:17506035-Interleukin-10,
pubmed-meshheading:17506035-Interleukin-12,
pubmed-meshheading:17506035-Interleukin-4,
pubmed-meshheading:17506035-Interleukin-5,
pubmed-meshheading:17506035-Lung,
pubmed-meshheading:17506035-Mice,
pubmed-meshheading:17506035-Mice, Inbred C57BL,
pubmed-meshheading:17506035-Mice, Knockout,
pubmed-meshheading:17506035-Receptors, Cytokine,
pubmed-meshheading:17506035-STAT4 Transcription Factor,
pubmed-meshheading:17506035-T-Box Domain Proteins,
pubmed-meshheading:17506035-Tumor Necrosis Factor-alpha,
pubmed-meshheading:17506035-Vascular Cell Adhesion Molecule-1
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pubmed:year |
2007
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pubmed:articleTitle |
Lung CD11c+ cells from mice deficient in Epstein-Barr virus-induced gene 3 (EBI-3) prevent airway hyper-responsiveness in experimental asthma.
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pubmed:affiliation |
Laboratory of Cellular and Molecular Lung Immunology, I Medical Clinic, University of Mainz, Mainz, Germany, and Institut Universitaire de Pathologie Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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