Source:http://linkedlifedata.com/resource/pubmed/id/17505016
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2007-9-5
|
| pubmed:abstractText |
Junctional adhesion molecule-A (JAM-A) is a transmembrane protein expressed at tight junctions of endothelial and epithelial cells and on the surface of platelets and leukocytes. The role of JAM-A in leukocyte transmigration in vivo was directly investigated by intravital microscopy using both a JAM-A-neutralizing monoclonal antibody (mAb) (BV-11) and JAM-A-deficient (knockout [KO]) mice. Leukocyte transmigration (but not adhesion) through mouse cremasteric venules as stimulated by interleukin 1beta (IL-1beta) or ischemia/reperfusion (I/R) injury was significantly reduced in wild-type mice treated with BV-11 and in JAM-A KO animals. In contrast, JAM-A blockade/genetic deletion had no effect on responses elicited by leukotriene B(4) (LTB(4)) or platelet-activating factor (PAF). Furthermore, using a leukocyte transfer method and mice deficient in endothelial-cell JAM-A, evidence was obtained for the involvement of endothelial-cell JAM-A in leukocyte transmigration mediated by IL-1beta. Investigation of the functional relationship between JAM-A and PECAM-1 (CD31) determined that dual blockade/deletion of these proteins does not lead to an inhibitory effect greater than that seen with blockade/deletion of either molecule alone. The latter appeared to be due to the fact that JAM-A and PECAM-1 can act sequentially to mediate leukocyte migration through venular walls in vivo.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD31,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/F11r protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0006-4971
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| pubmed:author |
pubmed-author:CoradaMonicaM,
pubmed-author:DejanaElisabettaE,
pubmed-author:HaskardDorian ODO,
pubmed-author:KhandogaAndrejA,
pubmed-author:KrombachFritzF,
pubmed-author:NoursharghSussanS,
pubmed-author:ReichelChristoph AndreasCA,
pubmed-author:ScheiermannChristophC,
pubmed-author:VoisinMathieu-BenoitMB,
pubmed-author:WoodfinAbigailA
|
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
110
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1848-56
|
| pubmed:meshHeading |
pubmed-meshheading:17505016-Animals,
pubmed-meshheading:17505016-Antibodies, Monoclonal,
pubmed-meshheading:17505016-Antigens, CD31,
pubmed-meshheading:17505016-Cell Adhesion,
pubmed-meshheading:17505016-Cell Adhesion Molecules,
pubmed-meshheading:17505016-Cell Movement,
pubmed-meshheading:17505016-Disease Models, Animal,
pubmed-meshheading:17505016-Female,
pubmed-meshheading:17505016-Fluorescent Antibody Technique,
pubmed-meshheading:17505016-Leukocytes,
pubmed-meshheading:17505016-Male,
pubmed-meshheading:17505016-Mice,
pubmed-meshheading:17505016-Mice, Inbred C57BL,
pubmed-meshheading:17505016-Mice, Knockout,
pubmed-meshheading:17505016-Muscles,
pubmed-meshheading:17505016-Neutrophils,
pubmed-meshheading:17505016-Receptors, Cell Surface,
pubmed-meshheading:17505016-Reperfusion Injury
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
JAM-A mediates neutrophil transmigration in a stimulus-specific manner in vivo: evidence for sequential roles for JAM-A and PECAM-1 in neutrophil transmigration.
|
| pubmed:affiliation |
Cardiovascular Medicine Unit, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|