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rdf:type |
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lifeskim:mentions |
|
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pubmed:issue |
10
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pubmed:dateCreated |
2007-5-16
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|
pubmed:abstractText |
Heat shock protein 27 (Hsp27) is up-regulated in multiple malignancies and implicated in cisplatin resistance. It is attempted to know how Hsp27 endues cell with cisplatin resistance by interfering with upstream of both apoptosis signal-regulating kinase 1 (ASK1)/p38 mitogen-activated protein kinase-activated apoptotic signaling and serine/threonine kinase Akt-dependent survival signaling.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
|
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pubmed:issn |
1078-0432
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
13
|
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
2855-64
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17504983-Animals,
pubmed-meshheading:17504983-Antineoplastic Agents,
pubmed-meshheading:17504983-Apoptosis,
pubmed-meshheading:17504983-Cell Line, Tumor,
pubmed-meshheading:17504983-Cell Survival,
pubmed-meshheading:17504983-Cisplatin,
pubmed-meshheading:17504983-Enzyme Activation,
pubmed-meshheading:17504983-HeLa Cells,
pubmed-meshheading:17504983-Heat-Shock Proteins,
pubmed-meshheading:17504983-Humans,
pubmed-meshheading:17504983-Mice,
pubmed-meshheading:17504983-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:17504983-RNA, Small Interfering,
pubmed-meshheading:17504983-Thioredoxin-Disulfide Reductase,
pubmed-meshheading:17504983-p38 Mitogen-Activated Protein Kinases
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pubmed:year |
2007
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pubmed:articleTitle |
Heat shock protein 27 protects L929 cells from cisplatin-induced apoptosis by enhancing Akt activation and abating suppression of thioredoxin reductase activity.
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pubmed:affiliation |
Institute of Biophysics, Chinese Academy of Science, Graduate School of the Chinese Academy of Sciences, Beijing, P.R. China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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