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pubmed-article:17504906pubmed:abstractTextBecause sex steroids play an important role in bone development, variants in genes encoding proteins involved in estrogen synthesis and metabolism could contribute to interindividual variation in bone parameters and fracture risk. An example is catechol-O-methyltransferase (COMT), an estrogen-degrading enzyme involved in inactivation of catechol-estrogens. Its gene contains a functional valine to methionine substitution at codon 158.lld:pubmed
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pubmed-article:17504906pubmed:articleTitleThe catechol-O-methyltransferase Met158 low-activity allele and association with nonvertebral fracture risk in elderly men.lld:pubmed
pubmed-article:17504906pubmed:affiliationDepartment of Internal Medicine, Erasmus Medical Center, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands.lld:pubmed
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