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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2007-8-7
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pubmed:abstractText |
Because sex steroids play an important role in bone development, variants in genes encoding proteins involved in estrogen synthesis and metabolism could contribute to interindividual variation in bone parameters and fracture risk. An example is catechol-O-methyltransferase (COMT), an estrogen-degrading enzyme involved in inactivation of catechol-estrogens. Its gene contains a functional valine to methionine substitution at codon 158.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0021-972X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3206-12
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17504906-Aged,
pubmed-meshheading:17504906-Alleles,
pubmed-meshheading:17504906-Androstenedione,
pubmed-meshheading:17504906-Anthropometry,
pubmed-meshheading:17504906-Bone Density,
pubmed-meshheading:17504906-Bone and Bones,
pubmed-meshheading:17504906-Catechol O-Methyltransferase,
pubmed-meshheading:17504906-Cohort Studies,
pubmed-meshheading:17504906-Estradiol,
pubmed-meshheading:17504906-Estrogens,
pubmed-meshheading:17504906-Estrone,
pubmed-meshheading:17504906-Female,
pubmed-meshheading:17504906-Fractures, Bone,
pubmed-meshheading:17504906-Genetic Variation,
pubmed-meshheading:17504906-Genotype,
pubmed-meshheading:17504906-Humans,
pubmed-meshheading:17504906-Male,
pubmed-meshheading:17504906-Methionine,
pubmed-meshheading:17504906-Middle Aged,
pubmed-meshheading:17504906-Osteoblasts,
pubmed-meshheading:17504906-RNA, Messenger,
pubmed-meshheading:17504906-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17504906-Risk,
pubmed-meshheading:17504906-Testosterone
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pubmed:year |
2007
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pubmed:articleTitle |
The catechol-O-methyltransferase Met158 low-activity allele and association with nonvertebral fracture risk in elderly men.
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pubmed:affiliation |
Department of Internal Medicine, Erasmus Medical Center, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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