Linked Life Data

17504783

Source:http://linkedlifedata.com/resource/pubmed/id/17504783

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2007-12-10
pubmed:abstractText
The role of superior temporal cortex in speech comprehension is well established, but the complete network of regions involved in understanding language in ecologically valid contexts is less clearly understood. In a functional magnetic resonance imaging (fMRI) study, we presented 24 subjects with auditory or audiovisual narratives, and used model-free intersubject correlational analyses to reveal brain areas that were modulated in a consistent way across subjects during the narratives. Conventional comparisons to a resting state were also performed. Both analyses showed the expected recruitment of superior temporal areas, however, the intersubject correlational analyses also revealed an extended network of areas involved in narrative speech comprehension. Two findings stand out in particular. Firstly, many areas in the "default mode" network (typically deactivated relative to rest) were systematically modulated by the time-varying properties of the auditory or audiovisual input. These areas included the anterior cingulate and adjacent medial frontal cortex, and the posterior cingulate and adjacent precuneus. Secondly, extensive bilateral inferior frontal and premotor regions were implicated in auditory as well as audiovisual language comprehension. This extended network of regions may be important for higher-level linguistic processes, and interfaces with extralinguistic cognitive, affective, and interpersonal systems.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1460-2199
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
230-42
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Beyond superior temporal cortex: intersubject correlations in narrative speech comprehension.
pubmed:affiliation
Ahmanson-Lovelace Brain Mapping Center, Brain Research Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA. stephenw@ucla.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural