Linked Life Data

17504211

Source:http://linkedlifedata.com/resource/pubmed/id/17504211

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2007-5-16
pubmed:abstractText
Although alcohol is believed to exert deleterious effects on the nervous system in general, its specific effect on the brain's immune system remains poorly understood. In particular, the effects of alcohol consumption on the immune and inflammatory responses in the central nervous system (CNS) have not been extensively investigated. Here, reviewed is the recent progress on how ethanol influences the signal transduction pathways of the inflammatory activation of brain microglia, which are thought to function as the resident immune defense system of the brain. Microglia are the CNS representatives of macrophages, which have the ability to clean up cellular debris. Microglia participate in neuroinflammation in response to various intrinsic or extrinsic stimuli. It has been recently suggested that microglial signal transduction is one of the main targets of ethanol action in the brain: ethanol exposure selectively modulates the intracellular signal transductions of microglia, rather than globally inhibiting signaling pathways in a nonspecific manner. Deregulation by ethanol of the inflammatory activation signaling of microglia may contribute to the derangement of CNS immune and inflammatory responses.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1567-2026
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
131-42
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Microglial signal transduction as a target of alcohol action in the brain.
pubmed:affiliation
Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, 700-422 Korea. ksuk@knu.ac.kr
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't