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rdf:type |
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lifeskim:mentions |
umls-concept:C0014939,
umls-concept:C0033268,
umls-concept:C0034786,
umls-concept:C0086418,
umls-concept:C0138741,
umls-concept:C0205263,
umls-concept:C0332206,
umls-concept:C0334227,
umls-concept:C0376358,
umls-concept:C1366489,
umls-concept:C1417779,
umls-concept:C1514485
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pubmed:issue |
11
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pubmed:dateCreated |
2007-6-27
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pubmed:abstractText |
Dehydroepiandrosterone (DHEA) is an endogenous steroid that is metabolized to androgens and/or estrogens in the human prostate. DHEA levels decline with age, and use of DHEA supplements to retard the aging process is of unproved effectiveness and safety. LNCaP and LAPC-4 prostate cancer cells were used to determine whether DHEA-modulated proliferation and prostate specific antigen (PSA) production were mediated via the androgen receptor (AR) and/or ERbeta.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Androgen Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Androgen Receptor Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Anilides,
http://linkedlifedata.com/resource/pubmed/chemical/Dehydroepiandrosterone,
http://linkedlifedata.com/resource/pubmed/chemical/Estradiol,
http://linkedlifedata.com/resource/pubmed/chemical/Estrogen Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Estrogen Receptor beta,
http://linkedlifedata.com/resource/pubmed/chemical/Nitriles,
http://linkedlifedata.com/resource/pubmed/chemical/Prostate-Specific Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Androgen,
http://linkedlifedata.com/resource/pubmed/chemical/Testosterone,
http://linkedlifedata.com/resource/pubmed/chemical/Tosyl Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/bicalutamide,
http://linkedlifedata.com/resource/pubmed/chemical/dehydrotestosterone,
http://linkedlifedata.com/resource/pubmed/chemical/fulvestrant
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0270-4137
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pubmed:author |
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pubmed:copyrightInfo |
(c) 2007 Wiley-Liss, Inc.
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
67
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1152-62
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:17503469-Androgen Antagonists,
pubmed-meshheading:17503469-Androgen Receptor Antagonists,
pubmed-meshheading:17503469-Anilides,
pubmed-meshheading:17503469-Cell Division,
pubmed-meshheading:17503469-Cell Line, Tumor,
pubmed-meshheading:17503469-Dehydroepiandrosterone,
pubmed-meshheading:17503469-Estradiol,
pubmed-meshheading:17503469-Estrogen Antagonists,
pubmed-meshheading:17503469-Estrogen Receptor beta,
pubmed-meshheading:17503469-Gene Expression,
pubmed-meshheading:17503469-Humans,
pubmed-meshheading:17503469-Male,
pubmed-meshheading:17503469-Nitriles,
pubmed-meshheading:17503469-Prostate-Specific Antigen,
pubmed-meshheading:17503469-Prostatic Neoplasms,
pubmed-meshheading:17503469-RNA, Messenger,
pubmed-meshheading:17503469-RNA, Small Interfering,
pubmed-meshheading:17503469-Receptors, Androgen,
pubmed-meshheading:17503469-Testosterone,
pubmed-meshheading:17503469-Tosyl Compounds
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pubmed:year |
2007
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pubmed:articleTitle |
Androgen receptor or estrogen receptor-beta blockade alters DHEA-, DHT-, and E(2)-induced proliferation and PSA production in human prostate cancer cells.
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pubmed:affiliation |
Endocrine Section, Laboratory of Clinical Investigation, Division of Intramural Research, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, Maryland 20892-0933, USA. jarnold@mail.nih.gov
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural,
Research Support, N.I.H., Intramural
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