17502851

Source:http://linkedlifedata.com/resource/pubmed/id/17502851

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0003374, umls-concept:C0008269, umls-concept:C0025153, umls-concept:C0034417, umls-concept:C0243076, umls-concept:C0295352
pubmed:issue	5
pubmed:dateCreated	2007-7-2
pubmed:abstractText	The antimalarial compounds quinine, chloroquine and mefloquine affect the electrophysiological properties of Cys-loop receptors and have structural similarities to 5-HT(3) receptor antagonists. They may therefore act at 5-HT(3) receptors.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/, http://linkedlifedata.com/resource/pubmed/grant/051097, http://linkedlifedata.com/resource/pubmed/grant/081925
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/7502536
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Antimalarials, http://linkedlifedata.com/resource/pubmed/chemical/Chloroquine, http://linkedlifedata.com/resource/pubmed/chemical/Granisetron, http://linkedlifedata.com/resource/pubmed/chemical/Mefloquine, http://linkedlifedata.com/resource/pubmed/chemical/Quinine, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin, 5-HT3, http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Antagonists
pubmed:status	MEDLINE
pubmed:month	Jul
pubmed:issn	0007-1188
pubmed:author	pubmed-author:LochnerMM, pubmed-author:LummisS C RSC, pubmed-author:ThompsonA JAJ
pubmed:issnType	Print
pubmed:volume	151
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	666-77
pubmed:dateRevised	2010-4-28
pubmed:meshHeading	pubmed-meshheading:17502851-Algorithms, pubmed-meshheading:17502851-Animals, pubmed-meshheading:17502851-Antimalarials, pubmed-meshheading:17502851-Binding, Competitive, pubmed-meshheading:17502851-Cells, Cultured, pubmed-meshheading:17502851-Chloroquine, pubmed-meshheading:17502851-Dose-Response Relationship, Drug, pubmed-meshheading:17502851-Electrophysiology, pubmed-meshheading:17502851-Female, pubmed-meshheading:17502851-Granisetron, pubmed-meshheading:17502851-Kinetics, pubmed-meshheading:17502851-Mefloquine, pubmed-meshheading:17502851-Models, Molecular, pubmed-meshheading:17502851-Oocytes, pubmed-meshheading:17502851-Quinine, pubmed-meshheading:17502851-Radioligand Assay, pubmed-meshheading:17502851-Receptors, Serotonin, 5-HT3, pubmed-meshheading:17502851-Serotonin Antagonists, pubmed-meshheading:17502851-Xenopus laevis
pubmed:year	2007
pubmed:articleTitle	The antimalarial drugs quinine, chloroquine and mefloquine are antagonists at 5-HT3 receptors.
pubmed:affiliation	Department of Biochemistry, University of Cambridge, Cambridge, UK.
pubmed:publicationType	Journal Article, In Vitro, Research Support, Non-U.S. Gov't