17502835

Source:http://linkedlifedata.com/resource/pubmed/id/17502835

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0001721, umls-concept:C0010583, umls-concept:C0031327, umls-concept:C0032529, umls-concept:C0851347, umls-concept:C1382176, umls-concept:C1516213, umls-concept:C1556094
pubmed:issue	6
pubmed:dateCreated	2007-5-15
pubmed:abstractText	To evaluate the effects of genetic polymorphisms of drug metabolizing enzymes on the pharmacokinetics of cyclophosphamide and its active metabolite, 4-hydroxycyclophosphamide, and on the pharmacodynamics.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101231005
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/4-hydroxycyclophosphamide, http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, http://linkedlifedata.com/resource/pubmed/chemical/Aryl Hydrocarbon Hydroxylases, http://linkedlifedata.com/resource/pubmed/chemical/Cyclophosphamide, http://linkedlifedata.com/resource/pubmed/chemical/DNA, Neoplasm, http://linkedlifedata.com/resource/pubmed/chemical/Oxidoreductases, N-Demethylating, http://linkedlifedata.com/resource/pubmed/chemical/S-mephenytoin N-demethylase
pubmed:status	MEDLINE
pubmed:month	Jun
pubmed:issn	1744-6872
pubmed:author	pubmed-author:EbiHiromichiH, pubmed-author:FujikiYutoY, pubmed-author:ItohKuniakiK, pubmed-author:KanadaYoshihiroY, pubmed-author:KomagataSayakaS, pubmed-author:MinamiHironobuH, pubmed-author:MukaiHirofumiH, pubmed-author:NakajimaMikiM, pubmed-author:YokoiTsuyoshiT
pubmed:issnType	Print
pubmed:volume	17
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	431-45
pubmed:dateRevised	2008-11-21
pubmed:meshHeading	pubmed-meshheading:17502835-Adult, pubmed-meshheading:17502835-Aged, pubmed-meshheading:17502835-Alleles, pubmed-meshheading:17502835-Antineoplastic Agents, pubmed-meshheading:17502835-Aryl Hydrocarbon Hydroxylases, pubmed-meshheading:17502835-Base Sequence, pubmed-meshheading:17502835-Breast Neoplasms, pubmed-meshheading:17502835-Cyclophosphamide, pubmed-meshheading:17502835-DNA, Neoplasm, pubmed-meshheading:17502835-Female, pubmed-meshheading:17502835-Gene Frequency, pubmed-meshheading:17502835-Genotype, pubmed-meshheading:17502835-Humans, pubmed-meshheading:17502835-Introns, pubmed-meshheading:17502835-Japan, pubmed-meshheading:17502835-Lymphoma, pubmed-meshheading:17502835-Male, pubmed-meshheading:17502835-Middle Aged, pubmed-meshheading:17502835-Oxidoreductases, N-Demethylating, pubmed-meshheading:17502835-Pharmacogenetics, pubmed-meshheading:17502835-Polymorphism, Genetic, pubmed-meshheading:17502835-Promoter Regions, Genetic
pubmed:year	2007
pubmed:articleTitle	Genetic polymorphisms of CYP2B6 affect the pharmacokinetics/pharmacodynamics of cyclophosphamide in Japanese cancer patients.
pubmed:affiliation	Drug Metabolism and Toxicology, Division of Pharmaceutical Sciences, Graduate School of Medical Science, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.
pubmed:publicationType	Journal Article