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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1976-4-29
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pubmed:abstractText |
Studies with the divalent cation ionophore A23187 suggest that both Ca2+ and Mg2+ ion influx play a role in human peripheral blood neutrophil function. Degranulation of neutrophils occurred at ionophore concentrations of 10(-5) M and was Ca2+ but not Mg2+ dependent. Modulation of neutrophil chemotaxis was enhanced optimally by 10(-7) M ionophore and was both Ca2+ and Mg2+ dependent. Concentrations of ionophore as low as 10(-12) M seemed to sensitize the cells to a concentration of phorbol myristate acetate which by itself was not chemotactic. These findings also indicate that factors other than Ca2+ or increases in cyclic nucleotides are important to initiation and modulation of neutrophil function.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/175014-1180327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/175014-14075014,
http://linkedlifedata.com/resource/pubmed/commentcorrection/175014-14934741,
http://linkedlifedata.com/resource/pubmed/commentcorrection/175014-164009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/175014-4126372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/175014-4150323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/175014-4151956,
http://linkedlifedata.com/resource/pubmed/commentcorrection/175014-4282929,
http://linkedlifedata.com/resource/pubmed/commentcorrection/175014-4318972,
http://linkedlifedata.com/resource/pubmed/commentcorrection/175014-4355374,
http://linkedlifedata.com/resource/pubmed/commentcorrection/175014-4356150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/175014-4357615,
http://linkedlifedata.com/resource/pubmed/commentcorrection/175014-4371752,
http://linkedlifedata.com/resource/pubmed/commentcorrection/175014-4421600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/175014-4611227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/175014-4819643,
http://linkedlifedata.com/resource/pubmed/commentcorrection/175014-4855032
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
146-51
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:175014-Anti-Bacterial Agents,
pubmed-meshheading:175014-Calcimycin,
pubmed-meshheading:175014-Calcium,
pubmed-meshheading:175014-Cations, Divalent,
pubmed-meshheading:175014-Chemotaxis,
pubmed-meshheading:175014-Cyclic GMP,
pubmed-meshheading:175014-Cytoplasmic Granules,
pubmed-meshheading:175014-Humans,
pubmed-meshheading:175014-Magnesium,
pubmed-meshheading:175014-Neutrophils,
pubmed-meshheading:175014-Tetradecanoylphorbol Acetate
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pubmed:year |
1976
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pubmed:articleTitle |
Role of Ca2+ and Mg2+ in some human neutrophil functions as indicated by ionophore A23187.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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