Source:http://linkedlifedata.com/resource/pubmed/id/17499830
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2007-6-8
|
| pubmed:abstractText |
The skin cancer enhancing effect of chromium (in male mice) and nickel in UVR-irradiated female Skh1 mice was investigated. The dietary vitamin E and selenomethionine were tested for prevention of chromium-enhanced skin carcinogenesis. The mice were exposed to UVR (1.0 kJ/m(2) 3 x weekly) for 26 weeks either alone, or combined with 2.5 or 5.0 ppm potassium chromate, or with 20, 100 or 500 ppm nickel chloride in drinking water. Vitamin E or selenomethionine was added to the lab chow for 29 weeks beginning 3 weeks before the start of UVR exposure. Both chromium and nickel significantly increased the UVR-induced skin cancer yield in mice. In male Skh1 mice, UVR alone induced 1.9+/-0.4 cancers/mouse, and 2.5 or 5.0 ppm potassium chromate added to drinking water increased the yields to 5.9+/-0.8 and 8.6+/-0.9 cancers/mouse, respectively. In female Skh1 mice, UVR alone induced 1.7+/-0.4 cancers/mouse, and the addition of 20, 100 or 500 ppm nickel chloride increased the yields to 2.8+/-0.9, 5.6+/-0.7 and 4.2+/-1.0 cancers/mouse, respectively. Neither vitamin E nor selenomethionine reduced the cancer yield enhancement by chromium. These results confirm that chromium and nickel, while not good skin carcinogens per se, are enhancers of UVR-induced skin cancers in Skh1 mice. Data also suggest that the enhancement of UVR-induced skin cancers by chromate may not be oxidatively mediated since the antioxidant vitamin E as well as selenomethionine, found to prevent arsenite-enhanced skin carcinogenesis, failed to suppress enhancement by chromate.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0041-008X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
221
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
329-38
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:17499830-Administration, Oral,
pubmed-meshheading:17499830-Animals,
pubmed-meshheading:17499830-Chromium Compounds,
pubmed-meshheading:17499830-Dose-Response Relationship, Drug,
pubmed-meshheading:17499830-Environmental Exposure,
pubmed-meshheading:17499830-Female,
pubmed-meshheading:17499830-Male,
pubmed-meshheading:17499830-Mice,
pubmed-meshheading:17499830-Mice, Hairless,
pubmed-meshheading:17499830-Neoplasms, Radiation-Induced,
pubmed-meshheading:17499830-Nickel,
pubmed-meshheading:17499830-Oxidative Stress,
pubmed-meshheading:17499830-Radiation-Sensitizing Agents,
pubmed-meshheading:17499830-Sex Factors,
pubmed-meshheading:17499830-Skin,
pubmed-meshheading:17499830-Skin Neoplasms,
pubmed-meshheading:17499830-Statistics, Nonparametric,
pubmed-meshheading:17499830-Sunlight,
pubmed-meshheading:17499830-Trace Elements,
pubmed-meshheading:17499830-Ultraviolet Rays
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
Dietary chromium and nickel enhance UV-carcinogenesis in skin of hairless mice.
|
| pubmed:affiliation |
Nelson Institute of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|