Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2007-6-18
pubmed:abstractText
The exon-intron structure of eukaryotic genes allows for phenomena such as alternative splicing, nonsense-mediated decay, and regulation through untranslated regions. However, the evolution of the exon structure of genes is not well elucidated because of limited and phylogenetically sparse data sets. In this study, we use the phylogenetically diverse sequencing of the ENCODE regions to study gene structure evolution in mammalian genomes. This first phylogenetically diverse study of gene structure changes offers insights into the mode and tempo of mammalian gene structure evolution. The genes undergoing structure changes appear to be moderately to highly expressed in germline cells and show levels of selection similar to those of other ENCODE genes. Patterns of gene duplication of the affected genes are more complex than expected. The number of sampled genomes is sufficiently dense to infer that certain gene duplications happened after intron loss. Thus, although gene duplication is highly correlated with intron loss, we conclude that structural changes in genes are not necessarily due to a loss of constraint following gene duplication as previously suggested.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17499477-10958630, http://linkedlifedata.com/resource/pubmed/commentcorrection/17499477-11063693, http://linkedlifedata.com/resource/pubmed/commentcorrection/17499477-11904358, http://linkedlifedata.com/resource/pubmed/commentcorrection/17499477-11932250, http://linkedlifedata.com/resource/pubmed/commentcorrection/17499477-12519945, http://linkedlifedata.com/resource/pubmed/commentcorrection/17499477-12777620, http://linkedlifedata.com/resource/pubmed/commentcorrection/17499477-12956953, http://linkedlifedata.com/resource/pubmed/commentcorrection/17499477-15014153, http://linkedlifedata.com/resource/pubmed/commentcorrection/17499477-15084679, http://linkedlifedata.com/resource/pubmed/commentcorrection/17499477-15231741, http://linkedlifedata.com/resource/pubmed/commentcorrection/17499477-15243155, http://linkedlifedata.com/resource/pubmed/commentcorrection/17499477-15499007, http://linkedlifedata.com/resource/pubmed/commentcorrection/17499477-15562318, http://linkedlifedata.com/resource/pubmed/commentcorrection/17499477-15642949, http://linkedlifedata.com/resource/pubmed/commentcorrection/17499477-15687506, http://linkedlifedata.com/resource/pubmed/commentcorrection/17499477-15827119, http://linkedlifedata.com/resource/pubmed/commentcorrection/17499477-16280547, http://linkedlifedata.com/resource/pubmed/commentcorrection/17499477-16389300, http://linkedlifedata.com/resource/pubmed/commentcorrection/17499477-16518452, http://linkedlifedata.com/resource/pubmed/commentcorrection/17499477-16600017, http://linkedlifedata.com/resource/pubmed/commentcorrection/17499477-16719932, http://linkedlifedata.com/resource/pubmed/commentcorrection/17499477-16925836, http://linkedlifedata.com/resource/pubmed/commentcorrection/17499477-6186397
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0888-7543
pubmed:author
pubmed:issnType
Print
pubmed:volume
90
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
44-8
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Patterns of gene duplication and intron loss in the ENCODE regions suggest a confounding factor.
pubmed:affiliation
Genome Center, University of California at Davis, Davis, CA 95616, USA. schatterji@ucdavis.edu
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural