Linked Life Data

17499474

Source:http://linkedlifedata.com/resource/pubmed/id/17499474

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2008-3-25
pubmed:abstractText
Enantiomeric separations of four 2-substituted propionic acid drugs and two related acids have been studied using normal phase liquid chromatography with amylose (tris 3,5-dimethylphenylcarbamate) coated on silica as support (Chiralpak AD). At standard conditions (i.e. flow-rate, 1.0 ml/min; column temperature, 30 degrees C) the elution order can be reversed when the polar alcohol modifier in isohexane, 2-propanol, is replaced by methanol/ethanol 2:1. This is the case for ibuprofen with 2.5% (v/v) alcohol and for mandelic acid with 10% (v/v) alcohol using synthetic mixtures with unequal proportions of the respective enantiomer. Thermodynamic studies in the range 10-45 degrees C on retention and selectivity of ibuprofen and mandelic acid gave both linear and curved plots. These results stress the importance of investigating enantiomer elution order during the development of enantioselective methods when both old and new CSPs are evaluated. One should also keep in mind that reversal can take place for rather common analytes in well established enantioselective chromatographic systems.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0731-7085
pubmed:author
pubmed:issnType
Print
pubmed:day
14
pubmed:volume
46
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
860-3
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Reversal of elution order for profen acid enantiomers in normal phase LC on Chiralpak AD.
pubmed:affiliation
Analytical Development, Pharmaceutical and Analytical R&D, AstraZeneca R&D Mölndal, S 431 83 Mölndal, Sweden.
pubmed:publicationType
Journal Article