Linked Life Data

17499199

Source:http://linkedlifedata.com/resource/pubmed/id/17499199

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2007-5-14
pubmed:abstractText
There have been a number of reports showing that the crude beta-glucan fraction prepared from various kinds of Basidiomycetes mushrooms acts as anti-cancer and anti-allergic reagent through stimulation of IFN-gamma production. It has been reported, however, that the exposure of the airway to beta-(1,3) d-glucan, contained in house dust, indoor moulds and some bacteria, potentiates the airway allergic response. It seems likely that the discrepant effects on immune function may be related to such factors as differences of the administration route, average molecular weight and water solubility. We isolated a new low-molecular-weight (about 100 kDa) beta-glucan from Aureobasidium pullulans 1A1 strain of black yeast, and found that it had low viscosity and was water-soluble. In this study, we examined the effects of water-soluble low-molecular-weight beta-(1-->3) and 50-80% branched beta-(1-->6) glucan (LMW-beta-Glucan) isolated from A. pullulans on the ova-albumin (OVA)-treated allergic reaction in mice. Feeding standard laboratory diets containing 0.5 and 1% LMW-beta-Glucan significantly inhibited the OVA-specific IgE elevation compared to that in OVA-sensitized mice fed standard laboratory diet alone (control). Furthermore, feeding standard laboratory diets containing 0.5 and 1% LMW-beta-Glucan inhibited the reduction of IL-12 and IFN-gamma production from splenocytes and the reduction of CD8- and IFN-gamma-positive cell number in the small intestine of the OVA-sensitized mice. These findings suggest that anti-food allergic action of LMW-beta-Glucan may be due to the inducing IFN-gamma production in the small intestine and splenocytes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1567-5769
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
963-72
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:17499199-Animal Feed, pubmed-meshheading:17499199-Animals, pubmed-meshheading:17499199-Anti-Allergic Agents, pubmed-meshheading:17499199-Antineoplastic Agents, pubmed-meshheading:17499199-Basidiomycota, pubmed-meshheading:17499199-Carbohydrate Sequence, pubmed-meshheading:17499199-Cytokines, pubmed-meshheading:17499199-Dose-Response Relationship, Drug, pubmed-meshheading:17499199-Down-Regulation, pubmed-meshheading:17499199-Food Hypersensitivity, pubmed-meshheading:17499199-Glucans, pubmed-meshheading:17499199-Hypersensitivity, pubmed-meshheading:17499199-Immunoglobulin E, pubmed-meshheading:17499199-Immunologic Factors, pubmed-meshheading:17499199-Male, pubmed-meshheading:17499199-Mice, pubmed-meshheading:17499199-Mice, Inbred BALB C, pubmed-meshheading:17499199-Molecular Weight, pubmed-meshheading:17499199-Ovalbumin, pubmed-meshheading:17499199-Solubility, pubmed-meshheading:17499199-Spleen, pubmed-meshheading:17499199-Water
pubmed:year
2007
pubmed:articleTitle
Inhibitory effects of water-soluble low-molecular-weight beta-(1,3-1,6) d-glucan purified from Aureobasidium pullulans GM-NH-1A1 strain on food allergic reactions in mice.
pubmed:affiliation
Division of Biochemical Pharmacology, Department of Basic Medical Research, Graduate School of Medicine, Ehime University, Shitsukawa, Toon-City, Ehime 791-0295, Japan. yokim@m.ehime-u.ac.jp
pubmed:publicationType
Journal Article