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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2007-6-5
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pubmed:abstractText |
The case fatality for intentional self-poisoning in rural Asia is 10-30 times higher than in the West, mostly due to the use of highly toxic poisons. Activated charcoal is a widely available intervention that may - if given early - bind to poisons in the stomach and prevent their absorption. Current guidelines recommend giving a single dose of charcoal (SDAC) if patients arrive within an hour of ingestion. Multiple doses (MDAC) may increase poison elimination at a later time by interrupting any enterohepatic or enterovascular circulations. The effectiveness of SDAC or MDAC is unknown. Since most patients present to hospital after one hour, we considered MDAC to have a higher likelihood of clinical benefit and set up a study to compare MDAC with no charcoal. A third arm of SDAC was added to help determine whether any benefit noted from MDAC resulted from the first dose or all doses.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17498281-10584586,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17498281-10768435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17498281-11323066,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17498281-12801736,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17498281-14522536,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17498281-14703547,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17498281-15083947,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17498281-15214617,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17498281-15566582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17498281-15641639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17498281-7110218,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17498281-7650764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17498281-795448,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17498281-9460829,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17498281-9482425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17498281-9482426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17498281-9482427
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pubmed:language |
eng
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pubmed:journal |
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pubmed:status |
PubMed-not-MEDLINE
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pubmed:issn |
1471-227X
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pubmed:author |
pubmed-author:AllenStuartS,
pubmed-author:AzherShifaS,
pubmed-author:BuckleyNick ANA,
pubmed-author:DissanayakeWasanthaW,
pubmed-author:EddlestonMichaelM,
pubmed-author:FahimMohammedM,
pubmed-author:HittarageAriyasenaA,
pubmed-author:JayamanneShalukaS,
pubmed-author:JeganathanKK,
pubmed-author:JuszczakEdmundE,
pubmed-author:Ox-Col Poisoning Study collaborators,
pubmed-author:SenarathnaLalithL,
pubmed-author:SheriffM H RezviMH,
pubmed-author:WarrellDavid ADA
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pubmed:issnType |
Electronic
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2
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pubmed:dateRevised |
2009-12-29
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pubmed:year |
2007
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pubmed:articleTitle |
Study protocol: a randomised controlled trial of multiple and single dose activated charcoal for acute self-poisoning.
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pubmed:affiliation |
Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, UK. eddlestonm@yahoo.com
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pubmed:publicationType |
Journal Article
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