|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2007-5-14
|
|
pubmed:abstractText |
Hepatitis B virus (HBV) immune escape mutants with point mutations within the S gene may arise during the natural course of HBV infection, due to a positive selection pressure exerted by the host immune response. Mutations within the immunodominant B and T cell epitopes of hepatitis B surface antigen (HBsAg) allow the resulting S-mutants to propagate even in the presence of neutralizing anti-HBs antibodies and the HBV-specific T-cell immune response.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
1478-3223
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
27
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
727-30
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:17498261-Adult,
pubmed-meshheading:17498261-Antiviral Agents,
pubmed-meshheading:17498261-Hepatitis B, Chronic,
pubmed-meshheading:17498261-Hepatitis B Antibodies,
pubmed-meshheading:17498261-Hepatitis B Surface Antigens,
pubmed-meshheading:17498261-Hepatitis B virus,
pubmed-meshheading:17498261-Humans,
pubmed-meshheading:17498261-Interferon-alpha,
pubmed-meshheading:17498261-Male,
pubmed-meshheading:17498261-Mutation,
pubmed-meshheading:17498261-Polyethylene Glycols,
pubmed-meshheading:17498261-Recombinant Proteins
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Successful interferon treatment in a patient chronically infected with hepatitis B virus carrying unusual S- (and P-) mutants in the presence of anti-HBs antibodies.
|
|
pubmed:affiliation |
Departamento de Medicina - Hepatología, Hospital Argerich, Asociado a la Universidad de Buenos Aires (UBA), Buenos Aires, Argentina. bernardo@frider.com.ar
|
|
pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
|
