Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2007-5-17
pubmed:abstractText
This study compared the effects of di(n-butyl) phthalate (DBP) on the oxidative damage and antioxidant enzymes activity in testes of hyperthyroid rats. Hyperthyroidism was induced in pubertal male rats by intraperitoneal injection of triiodothyronine (T3, 10 microg/kg body weight) for 30 days. An oral dose of DBP (750 mg/kg) was administered simultaneously to normal or hyperthyroid (T3) rats over a 30-day period. No changes in body weight were observed in the hyperthyroid groups (T3, T3 + DBP) compared with controls. There were significantly higher serum T3 levels observed in the hyperthyroid rats than in the control, but the serum thyroid stimulating hormone levels were markedly lower in the hyperthyroid rats. DBP significantly decreased the weight of the testes in the normal (DBP) and hyperthyroid (T3 + DBP) groups. The serum testosterone concentrations were significantly lower in only DBP group. DBP significantly increased the 8-hydroxy-2-deoxyguanosine (8-OHdG) level in the testes, whereas the DBP-induced 8-OHdG levels were slightly higher in T3 + DBP group. Superoxide dismutase and glutathione peroxidase activities were significantly higher in the testes of the DBP or T3 + DBP groups. Catalase (CAT) activity was significantly higher in the DBP treatment group, but the T3 + DBP group showed slightly lower DBP-induced CAT activity. The testicular expression of thyroid hormone receptor alpha-1 (TRalpha-1) was significantly higher in the DBP groups, and androgen receptor (AR) expression was not detected in the DBP treatment group. In addition, DBP significantly increased the peroxisome proliferator-activated receptor-r (PPAR-r) levels in the testis. These results suggest that hyperthyroidism can cause a change in the expression level of PPAR-r in testes, and may increase the levels of oxidative damage induced by the metabolic activation of DBP.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Catalase, http://linkedlifedata.com/resource/pubmed/chemical/Deoxyguanosine, http://linkedlifedata.com/resource/pubmed/chemical/Dibutyl Phthalate, http://linkedlifedata.com/resource/pubmed/chemical/Enzymes, http://linkedlifedata.com/resource/pubmed/chemical/Glutathione Peroxidase, http://linkedlifedata.com/resource/pubmed/chemical/Malondialdehyde, http://linkedlifedata.com/resource/pubmed/chemical/PPAR alpha, http://linkedlifedata.com/resource/pubmed/chemical/Plasticizers, http://linkedlifedata.com/resource/pubmed/chemical/Superoxide Dismutase, http://linkedlifedata.com/resource/pubmed/chemical/Testosterone, http://linkedlifedata.com/resource/pubmed/chemical/Thyroid Hormone Receptors alpha, http://linkedlifedata.com/resource/pubmed/chemical/Thyrotropin, http://linkedlifedata.com/resource/pubmed/chemical/Triiodothyronine
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1520-4081
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
245-55
pubmed:meshHeading
pubmed-meshheading:17497641-Animals, pubmed-meshheading:17497641-Catalase, pubmed-meshheading:17497641-Deoxyguanosine, pubmed-meshheading:17497641-Dibutyl Phthalate, pubmed-meshheading:17497641-Enzymes, pubmed-meshheading:17497641-Glutathione Peroxidase, pubmed-meshheading:17497641-Hyperthyroidism, pubmed-meshheading:17497641-Male, pubmed-meshheading:17497641-Malondialdehyde, pubmed-meshheading:17497641-Organ Size, pubmed-meshheading:17497641-Oxidation-Reduction, pubmed-meshheading:17497641-PPAR alpha, pubmed-meshheading:17497641-Plasticizers, pubmed-meshheading:17497641-Rats, pubmed-meshheading:17497641-Rats, Sprague-Dawley, pubmed-meshheading:17497641-Superoxide Dismutase, pubmed-meshheading:17497641-Testicular Diseases, pubmed-meshheading:17497641-Testis, pubmed-meshheading:17497641-Testosterone, pubmed-meshheading:17497641-Thyroid Hormone Receptors alpha, pubmed-meshheading:17497641-Thyrotropin, pubmed-meshheading:17497641-Triiodothyronine
pubmed:year
2007
pubmed:articleTitle
Effect of di(n-butyl) phthalate on testicular oxidative damage and antioxidant enzymes in hyperthyroid rats.
pubmed:affiliation
Laboratory of Molecular Toxicology, College of Pharmacy, Pusan National University, San 30, Jangjun-Dong, Gumjung-Ku, Busan, South Korea.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't