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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2007-5-14
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pubmed:abstractText |
The serotonin [5-hydroxytryptamine (5-HT)]-gated ion channel 5-HT3 is involved in the mediation of postoperative and radiotherapy/chemotherapy-induced nausea/emesis and in irritable bowel syndrome. It has also been suggested to play a role in various psychiatric diseases. Five naturally occurring single nucleotide polymorphisms leading to amino acid changes have been identified in the human 5-HT3A gene.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1744-6872
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
255-66
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17496724-Animals,
pubmed-meshheading:17496724-COS Cells,
pubmed-meshheading:17496724-Cercopithecus aethiops,
pubmed-meshheading:17496724-Gene Expression,
pubmed-meshheading:17496724-Genetic Variation,
pubmed-meshheading:17496724-Humans,
pubmed-meshheading:17496724-Kinetics,
pubmed-meshheading:17496724-Pharmacogenetics,
pubmed-meshheading:17496724-Polymorphism, Single Nucleotide,
pubmed-meshheading:17496724-Protein Subunits,
pubmed-meshheading:17496724-Receptors, Serotonin, 5-HT3,
pubmed-meshheading:17496724-Recombinant Proteins,
pubmed-meshheading:17496724-Transfection
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pubmed:year |
2007
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|
pubmed:articleTitle |
Naturally occurring variations in the human 5-HT3A gene profoundly impact 5-HT3 receptor function and expression.
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pubmed:affiliation |
Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, Denmark.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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