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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2007-5-14
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pubmed:abstractText |
T-cell responses to minor histocompatibility antigens are mediators of graft-versus-host disease and organ graft rejection. We previously identified a human minor histocompatibility antigen that is recognized by CD8 cytotoxic T lymphocytes (CTLs) and encoded by the UDP glycosyltransferase 2 family, polypeptide B17 (UGT2B17) gene, which is highly expressed in the liver, colon, and small intestine. The UGT2B17 is presented by human leukocyte antigen (HLA)-A*2902, and the immunogenicity of this minor histocompatibility antigen results from differential protein expression in donor and recipient cells as a consequence of a UGT2B17 gene deletion.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/Glucuronosyltransferase,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-A Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-B*44:03 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-B Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-B44 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Minor Histocompatibility Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/UGT2B17 protein, human
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0041-1337
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
83
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1242-8
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:17496542-Amino Acid Sequence,
pubmed-meshheading:17496542-Animals,
pubmed-meshheading:17496542-Base Sequence,
pubmed-meshheading:17496542-COS Cells,
pubmed-meshheading:17496542-Cells, Cultured,
pubmed-meshheading:17496542-Cercopithecus aethiops,
pubmed-meshheading:17496542-Clone Cells,
pubmed-meshheading:17496542-Epitopes,
pubmed-meshheading:17496542-Gastrointestinal Diseases,
pubmed-meshheading:17496542-Glucuronosyltransferase,
pubmed-meshheading:17496542-Graft vs Host Disease,
pubmed-meshheading:17496542-HLA-A Antigens,
pubmed-meshheading:17496542-HLA-B Antigens,
pubmed-meshheading:17496542-HLA-B44 Antigen,
pubmed-meshheading:17496542-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:17496542-Histocompatibility Antigens,
pubmed-meshheading:17496542-Humans,
pubmed-meshheading:17496542-Liver Diseases,
pubmed-meshheading:17496542-Minor Histocompatibility Antigens,
pubmed-meshheading:17496542-Molecular Sequence Data,
pubmed-meshheading:17496542-Peptide Fragments,
pubmed-meshheading:17496542-T-Lymphocytes, Cytotoxic
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pubmed:year |
2007
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pubmed:articleTitle |
A single minor histocompatibility antigen encoded by UGT2B17 and presented by human leukocyte antigen-A*2902 and -B*4403.
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pubmed:affiliation |
Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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