Source:http://linkedlifedata.com/resource/pubmed/id/17495183
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
2007-5-14
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| pubmed:abstractText |
We recently showed that long-term weight reduction changes the gene expression profile of adipose tissue in overweight individuals with impaired glucose tolerance (IGT). One of the responding genes was X-chromosomal tenomodulin (TNMD), a putative angiogenesis inhibitor. Our aim was to study the associations of individual single nucleotide polymorphisms and haplotypes with adiposity, glucose metabolism, and the risk of type 2 diabetes (T2D). Seven single nucleotide polymorphisms from two different haploblocks were genotyped from 507 participants of the Finnish Diabetes Prevention Study (DPS). Sex-specific genotype effects were observed. Three markers of haploblock 1 were associated with features of adiposity in women (rs5966709, rs4828037) and men (rs11798018). Markers rs2073163 and rs1155794 from haploblock 2 were associated with 2-hour plasma glucose levels in men during the 3-year follow-up. The same two markers together with rs2073162 associated with the conversion of IGT to T2D in men. The risk of developing T2D was approximately 2-fold in individuals with genotypes associated with higher 2-hour plasma glucose levels; the hazard ratios were 2.192 (p = 0.025) for rs2073162-A, 2.191 (p = 0.027) for rs2073163-C, and 1.998 (p = 0.054) for rs1155974-T. These results suggest that TNMD polymorphisms are associated with adiposity and also with glucose metabolism and conversion from IGT to T2D in men.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
1930-7381
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
15
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1082-8
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| pubmed:dateRevised |
2008-1-21
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| pubmed:meshHeading |
pubmed-meshheading:17495183-Adult,
pubmed-meshheading:17495183-Body Mass Index,
pubmed-meshheading:17495183-Diabetes Mellitus,
pubmed-meshheading:17495183-Diet,
pubmed-meshheading:17495183-Exercise,
pubmed-meshheading:17495183-Female,
pubmed-meshheading:17495183-Finland,
pubmed-meshheading:17495183-Genotype,
pubmed-meshheading:17495183-Glucose Intolerance,
pubmed-meshheading:17495183-Glucose Tolerance Test,
pubmed-meshheading:17495183-Humans,
pubmed-meshheading:17495183-Male,
pubmed-meshheading:17495183-Membrane Proteins,
pubmed-meshheading:17495183-Middle Aged,
pubmed-meshheading:17495183-Obesity,
pubmed-meshheading:17495183-Patient Selection,
pubmed-meshheading:17495183-Polymorphism, Genetic,
pubmed-meshheading:17495183-Software
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| pubmed:year |
2007
|
| pubmed:articleTitle |
Tenomodulin is associated with obesity and diabetes risk: the Finnish diabetes prevention study.
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| pubmed:affiliation |
Department of Clinical Nutrition and Food and Health Research Centre, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland. Anna-Maija.Tolppanen@uku.fi
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| pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study
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