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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2007-5-14
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pubmed:abstractText |
In cystic fibrosis (CF) patients, the absence or dysfunction of the chloride channel CF transmembrane conductance regulator (CFTR) results in reduced chloride ion transport in respiratory epithelial cells. Moli1901 stimulates an alternative chloride channel and may thus compensate for the CFTR deficiency in the airway epithelium of CF patients.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0012-3692
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
131
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1461-6
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pubmed:meshHeading |
pubmed-meshheading:17494794-Administration, Inhalation,
pubmed-meshheading:17494794-Adolescent,
pubmed-meshheading:17494794-Adult,
pubmed-meshheading:17494794-Chloride Channels,
pubmed-meshheading:17494794-Cystic Fibrosis,
pubmed-meshheading:17494794-Cystic Fibrosis Transmembrane Conductance Regulator,
pubmed-meshheading:17494794-Dose-Response Relationship, Drug,
pubmed-meshheading:17494794-Double-Blind Method,
pubmed-meshheading:17494794-Female,
pubmed-meshheading:17494794-Forced Expiratory Volume,
pubmed-meshheading:17494794-Humans,
pubmed-meshheading:17494794-Male,
pubmed-meshheading:17494794-Peptides, Cyclic,
pubmed-meshheading:17494794-Respiratory Mucosa
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pubmed:year |
2007
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pubmed:articleTitle |
Inhalation of Moli1901 in patients with cystic fibrosis.
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pubmed:affiliation |
The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada. hartmut.grasemann@sickkids.ca
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Clinical Trial, Phase II
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