Linked Life Data

17494606

Source:http://linkedlifedata.com/resource/pubmed/id/17494606

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1 Suppl
pubmed:dateCreated
2007-5-14
pubmed:abstractText
H5N1 avian influenza viruses circulating in early 2004 in eastern Asia appeared to be under strong purifying selection, except for the hemagglutinin (HA) and nonstructural 1 (NS1) genes, where few amino acid positions were found under positive selection pressure. To evaluate whether the widespread circulation of the H5N1 viruses in the following years was accompanied by a change in the evolution of the HA and NS1, phylogenetic and positive selection analyses were performed on 89 HA and 57 NS1 sequences. Results showed that the number of HA positively selected sites decreased compared to 2004; no selection pressure for NS1 was found. These findings suggest a possible change in the adaptation of the H5N1 virus to birds.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0005-2086
pubmed:author
pubmed:issnType
Print
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
455-60
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Evolutionary analysis of HA and NS1 genes of H5N1 influenza viruses in 2004-2005 epidemics.
pubmed:affiliation
Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanità, Viale Regina Elena, 299, Rome 00161, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't