Linked Life Data

17494602

Source:http://linkedlifedata.com/resource/pubmed/id/17494602

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1 Suppl
pubmed:dateCreated
2007-5-14
pubmed:abstractText
The avian influenza virus (AIV) has eight genomic segments (hemagglutinin [HA], neuraminidase [NA], RNA polymerase subunit A [PA], RNA polymerase subunit B1 [PB1], RNA polymerase subunit B2 [PB2], nucleoprotein [NP], nonstructural gene [NS], and matrix protein [M]). The genetic reassortments, recombinations, and mutations lead to a rapid emergence of novel genotypes of the AIVs during their evolution. These emerging viruses provide a large reservoir for pandemic strains. Here we describe a novel computational strategy for genetic reassortment identification. In contrast to the traditional phylogenetic approaches, our method views the genotypes through the modules in networks. Genetic segments with short phylogenetic distance are grouped into modules. Our method is not limited to the number of sequences. We applied this method in reassortment identification of NP segments in H5N1 AIVs. We identified two new potential reassortments for H5N1 AIVs beyond the reported genotypes in literature.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0005-2086
pubmed:author
pubmed:issnType
Print
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
434-9
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Computational identification of reassortments in avian influenza viruses.
pubmed:affiliation
Systems Biology Laboratory, Department of Microbiology, Miami University, Oxford, OH 45056, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't