| pubmed-article:17493824 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17493824 | lifeskim:mentions | umls-concept:C0596402 | lld:lifeskim |
| pubmed-article:17493824 | lifeskim:mentions | umls-concept:C0012920 | lld:lifeskim |
| pubmed-article:17493824 | lifeskim:mentions | umls-concept:C0034255 | lld:lifeskim |
| pubmed-article:17493824 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:17493824 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:17493824 | lifeskim:mentions | umls-concept:C0038477 | lld:lifeskim |
| pubmed-article:17493824 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:17493824 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:17493824 | pubmed:issue | 13 | lld:pubmed |
| pubmed-article:17493824 | pubmed:dateCreated | 2007-5-28 | lld:pubmed |
| pubmed-article:17493824 | pubmed:abstractText | Designed and synthesized were a series of pyridines substituted at 2, 4, and 6 positions with various 5- or 6-memberd heteroaromatics as antitumor agents. They were evaluated their topoisomerase I and II inhibitory activities along with cytotoxicities against several human cancer cell lines. Among the prepared compounds, 10-20 showed significant topoisomerase I or II inhibitory activities, and 21-26 showed considerable cytotoxicities against several human cancer cell lines. Structure-activity relationship study indicates that 4'-pyridine at 6-position of central pyridine plays a key role in biological activity. | lld:pubmed |
| pubmed-article:17493824 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17493824 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17493824 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17493824 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17493824 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17493824 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17493824 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17493824 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17493824 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17493824 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:17493824 | pubmed:issn | 0968-0896 | lld:pubmed |
| pubmed-article:17493824 | pubmed:author | pubmed-author:JeongTae... | lld:pubmed |
| pubmed-article:17493824 | pubmed:author | pubmed-author:LeeEung-SeokE... | lld:pubmed |
| pubmed-article:17493824 | pubmed:author | pubmed-author:NaYounghwaY | lld:pubmed |
| pubmed-article:17493824 | pubmed:author | pubmed-author:JeongByeong-S... | lld:pubmed |
| pubmed-article:17493824 | pubmed:author | pubmed-author:LeeChong-Soon... | lld:pubmed |
| pubmed-article:17493824 | pubmed:author | pubmed-author:JahngYurngdon... | lld:pubmed |
| pubmed-article:17493824 | pubmed:author | pubmed-author:BasnetArjunA | lld:pubmed |
| pubmed-article:17493824 | pubmed:author | pubmed-author:ThapaPritamP | lld:pubmed |
| pubmed-article:17493824 | pubmed:author | pubmed-author:KarkiRadhaR | lld:pubmed |
| pubmed-article:17493824 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17493824 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:17493824 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:17493824 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17493824 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17493824 | pubmed:pagination | 4351-9 | lld:pubmed |
| pubmed-article:17493824 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:17493824 | pubmed:meshHeading | pubmed-meshheading:17493824... | lld:pubmed |
| pubmed-article:17493824 | pubmed:meshHeading | pubmed-meshheading:17493824... | lld:pubmed |
| pubmed-article:17493824 | pubmed:meshHeading | pubmed-meshheading:17493824... | lld:pubmed |
| pubmed-article:17493824 | pubmed:meshHeading | pubmed-meshheading:17493824... | lld:pubmed |
| pubmed-article:17493824 | pubmed:meshHeading | pubmed-meshheading:17493824... | lld:pubmed |
| pubmed-article:17493824 | pubmed:meshHeading | pubmed-meshheading:17493824... | lld:pubmed |
| pubmed-article:17493824 | pubmed:meshHeading | pubmed-meshheading:17493824... | lld:pubmed |
| pubmed-article:17493824 | pubmed:meshHeading | pubmed-meshheading:17493824... | lld:pubmed |
| pubmed-article:17493824 | pubmed:meshHeading | pubmed-meshheading:17493824... | lld:pubmed |
| pubmed-article:17493824 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17493824 | pubmed:articleTitle | 2,4,6-Trisubstituted pyridines: Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship. | lld:pubmed |
| pubmed-article:17493824 | pubmed:affiliation | College of Pharmacy, Yeungnam University, Kyongsan 712-749, Republic of Korea. | lld:pubmed |
| pubmed-article:17493824 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17493824 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:17493824 | lld:chembl |
