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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
13
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pubmed:dateCreated |
2007-5-28
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pubmed:abstractText |
Designed and synthesized were a series of pyridines substituted at 2, 4, and 6 positions with various 5- or 6-memberd heteroaromatics as antitumor agents. They were evaluated their topoisomerase I and II inhibitory activities along with cytotoxicities against several human cancer cell lines. Among the prepared compounds, 10-20 showed significant topoisomerase I or II inhibitory activities, and 21-26 showed considerable cytotoxicities against several human cancer cell lines. Structure-activity relationship study indicates that 4'-pyridine at 6-position of central pyridine plays a key role in biological activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0968-0896
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4351-9
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:17493824-Antineoplastic Agents,
pubmed-meshheading:17493824-Cell Line, Tumor,
pubmed-meshheading:17493824-Drug Screening Assays, Antitumor,
pubmed-meshheading:17493824-Enzyme Inhibitors,
pubmed-meshheading:17493824-Humans,
pubmed-meshheading:17493824-Indicators and Reagents,
pubmed-meshheading:17493824-Pyridines,
pubmed-meshheading:17493824-Structure-Activity Relationship,
pubmed-meshheading:17493824-Topoisomerase I Inhibitors
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pubmed:year |
2007
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pubmed:articleTitle |
2,4,6-Trisubstituted pyridines: Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship.
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pubmed:affiliation |
College of Pharmacy, Yeungnam University, Kyongsan 712-749, Republic of Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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