Linked Life Data

17493663

Source:http://linkedlifedata.com/resource/pubmed/id/17493663

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5-6
pubmed:dateCreated
2007-7-10
pubmed:abstractText
In a previous study on Sicilian men, an association of the functional polymorphism Asp299Gly in the TLR4 gene was reported with longevity and a reduced risk of myocardial infarction (MI). Here, we sought to confirm the findings in our extensive collection of 273 long-lived men (95-107 years), 606 male early-onset MI patients and 594 appropriate controls from Germany. Despite sufficient statistical power to replicate the findings observed in the South Italians, our results rule out a noteworthy influence of the TLR4 polymorphism upon human longevity or MI in German men. Therefore, the previously described associations in Sicilians might reflect either population-specific or potentially false-positive results.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0047-6374
pubmed:author
pubmed:issnType
Print
pubmed:volume
128
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
409-11
pubmed:meshHeading
pubmed:articleTitle
Role of the toll-like receptor 4 polymorphism Asp299Gly in longevity and myocardial infarction in German men.
pubmed:affiliation
Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't