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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2007-6-11
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pubmed:abstractText |
Since the correlation between the serotonin (5-hydroxytryptamine, 5-HT) system and seizure activity remains to be clarified, we investigated the 5-HT system in the hippocampus of seizure-resistant (SR) and seizure-sensitive (SS) gerbils. There was no difference of the 5-HT system in the hippocampi of young animals (predisposed and juvenile gerbils) in both SR and SS gerbils. 5-HT immunoreactivity in the dorsal raphe nucleus and the median raphe nucleus was also similarly detected in both animal groups. As compared to SR adult gerbils, only 5-HT1A receptor immunoreactivity was selectively reduced in CA1 interneurons within SS adult gerbils. (+/-)-8-hydroxy-2-(di-n-propylamino)tetralin (a 5-HT1A receptor agonist, 1 and 2 mg/kg) markedly reduced paired-pulse inhibition in the CA1 region of SS adult gerbils only. These findings suggest that the selective reduction in 5-HT1A receptor expression on CA1 interneurons of SS adult gerbil may not be developmental defects, but be an acquired compensatory change induced by repeated seizure activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0006-8993
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
1154
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
181-93
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pubmed:dateRevised |
2007-10-24
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pubmed:meshHeading |
pubmed-meshheading:17493597-8-Hydroxy-2-(di-n-propylamino)tetralin,
pubmed-meshheading:17493597-Analysis of Variance,
pubmed-meshheading:17493597-Animals,
pubmed-meshheading:17493597-Cell Count,
pubmed-meshheading:17493597-Disease Models, Animal,
pubmed-meshheading:17493597-Dose-Response Relationship, Drug,
pubmed-meshheading:17493597-Electroencephalography,
pubmed-meshheading:17493597-Gene Expression Regulation,
pubmed-meshheading:17493597-Gerbillinae,
pubmed-meshheading:17493597-Glutamate Decarboxylase,
pubmed-meshheading:17493597-Hippocampus,
pubmed-meshheading:17493597-Interneurons,
pubmed-meshheading:17493597-Isoenzymes,
pubmed-meshheading:17493597-Receptor, Serotonin, 5-HT1A,
pubmed-meshheading:17493597-Seizures,
pubmed-meshheading:17493597-Serotonin,
pubmed-meshheading:17493597-Serotonin Plasma Membrane Transport Proteins
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pubmed:year |
2007
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pubmed:articleTitle |
Seizure activity selectively reduces 5-HT1A receptor immunoreactivity in CA1 interneurons in the hippocampus of seizure-prone gerbils.
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pubmed:affiliation |
Department of Anatomy, College of Medicine, Hallym University, Chunchon 200-702, South Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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