Source:http://linkedlifedata.com/resource/pubmed/id/17492788
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0001675,
umls-concept:C0011209,
umls-concept:C0013935,
umls-concept:C0026845,
umls-concept:C0027882,
umls-concept:C0225326,
umls-concept:C0231230,
umls-concept:C0332307,
umls-concept:C0332835,
umls-concept:C0392747,
umls-concept:C0443252,
umls-concept:C1448584,
umls-concept:C1514772,
umls-concept:C1882822
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| pubmed:issue |
9
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| pubmed:dateCreated |
2007-6-27
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| pubmed:abstractText |
Motoneuron death leads to muscle denervation and atrophy. Transplantation of embryonic neurons into peripheral nerves results in reinnervation and provides a strategy to rescue muscles from atrophy independent of neuron replacement in a damaged or diseased spinal cord. But the count of regenerating axons always exceeds the number of motor units in this model, so target-derived trophic factor levels may limit reinnervation. Our aim was to examine whether long-term infusion of fibroblast growth factor-6 (FGF-6) into denervated medial gastrocnemius muscles improved the function of muscles reinnervated from neurons transplanted into nerve of adult Fischer rats. Factor delivery (10 microg, 4 weeks) began after sciatic nerve transection. After a week of nerve degeneration, 1 million embryonic day 14-15 ventral spinal cord cells were transplanted into the distal tibial stump as a neuron source. Ten weeks later, neurons that expressed motoneuron markers survived in the nerves. More myelinated axons were in nerves to saline-treated muscles than in FGF-6-treated muscles. However, each group showed comparable reductions in muscle fiber atrophy because of reinnervation. Mean reinnervated fiber area was 43%-51% of non-denervated fibers. Denervated fiber area averaged 11%. FGF-6-treated muscles were more fatigable than other reinnervated muscles but had stronger motor units and fewer type I fibers than did saline-treated muscles. FGF-6 thus influenced function by changing the type of fiber reinnervated by transplanted neurons. Deficits in FGF-6 may also contribute to the increase in type I fibers in muscles reinnervated from peripheral axons, suggesting that the effects of FGF-6 on fiber type are independent of the neuron source used for reinnervation.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
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| pubmed:issn |
0360-4012
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
85
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1933-42
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:17492788-Animals,
pubmed-meshheading:17492788-Atrophy,
pubmed-meshheading:17492788-Axons,
pubmed-meshheading:17492788-Cell Count,
pubmed-meshheading:17492788-Cell Survival,
pubmed-meshheading:17492788-Cell Transplantation,
pubmed-meshheading:17492788-Female,
pubmed-meshheading:17492788-Fibroblast Growth Factor 6,
pubmed-meshheading:17492788-Immunohistochemistry,
pubmed-meshheading:17492788-Motor Neurons,
pubmed-meshheading:17492788-Muscle, Skeletal,
pubmed-meshheading:17492788-Muscle Fatigue,
pubmed-meshheading:17492788-Muscle Fibers, Skeletal,
pubmed-meshheading:17492788-Muscle Fibers, Slow-Twitch,
pubmed-meshheading:17492788-Nerve Fibers, Myelinated,
pubmed-meshheading:17492788-Nerve Regeneration,
pubmed-meshheading:17492788-Neuromuscular Junction,
pubmed-meshheading:17492788-Neurons,
pubmed-meshheading:17492788-Peripheral Nerves,
pubmed-meshheading:17492788-Proto-Oncogene Proteins,
pubmed-meshheading:17492788-Rats,
pubmed-meshheading:17492788-Rats, Inbred F344
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| pubmed:year |
2007
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| pubmed:articleTitle |
Long-term delivery of FGF-6 changes the fiber type and fatigability of muscle reinnervated from embryonic neurons transplanted into adult rat peripheral nerve.
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| pubmed:affiliation |
The Miami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, Florida 33136-2104, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|