|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2007-12-17
|
|
pubmed:abstractText |
We have investigated the roles of dopamine and cAMP-regulated phosphoprotein (DARPP-32) in the multidrug resistance (MDR) of gastric cancer cells and the possible underlying mechanisms. The up-regulation of DARPP-32 was found to significantly enhance the sensitivity of cells of human adriamycin (ADR)-resistant gastric adenocarcinoma cell line SGC7901/ADR to vincristine, ADR, 5-fludrouracil and cisplatin. The results of an in vivo drug sensitivity assay confirmed that DARPP-32 may play a specific role in the MDR of gastric cancer. DARPP-32 significantly down-regulated the expression of P-glycoprotein and zinc ribbon domain-containing 1 (ZNRD1), but did not alter the expression of MDR-associated protein or glutathione-S-transferase. The up-regulation of ZNRD1 significantly inhibited the drug sensitivity of gastric cancer cells over-expressing DARPP-32, indicating that ZNRD1 may be important in the DARPP-32-mediated MDR of gastric cancer. DARPP-32 was also able to significantly decrease the anti-apoptotic activity of SGC7901/ADR cells. Further study of the biological functions of DARPP-32 may be helpful for understanding the mechanisms of MDR of gastric cancer cells and developing possible strategies to treat gastric cancer.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine and cAMP-Regulated...,
http://linkedlifedata.com/resource/pubmed/chemical/PPP1R1B protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/ZNRD1 protein, human
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0163-2116
|
|
pubmed:author |
pubmed-author:BaiFeihuF,
pubmed-author:ChenZhenZ,
pubmed-author:FanDaimingD,
pubmed-author:GuoWeiW,
pubmed-author:HanYingY,
pubmed-author:HongLiuL,
pubmed-author:JinHaifengH,
pubmed-author:QiaoTaidongT,
pubmed-author:WildE AEA,
pubmed-author:ZhaiHuihongH,
pubmed-author:ZhangXiaoyinX,
pubmed-author:ZhaoYunpingY
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
53
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
101-7
|
|
pubmed:meshHeading |
pubmed-meshheading:17492506-Adenocarcinoma,
pubmed-meshheading:17492506-Antineoplastic Agents,
pubmed-meshheading:17492506-Apoptosis,
pubmed-meshheading:17492506-Blotting, Western,
pubmed-meshheading:17492506-Cell Line, Tumor,
pubmed-meshheading:17492506-DNA-Binding Proteins,
pubmed-meshheading:17492506-Dopamine and cAMP-Regulated Phosphoprotein 32,
pubmed-meshheading:17492506-Drug Resistance, Multiple,
pubmed-meshheading:17492506-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:17492506-Humans,
pubmed-meshheading:17492506-RNA, Neoplasm,
pubmed-meshheading:17492506-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17492506-Stomach Neoplasms,
pubmed-meshheading:17492506-Tumor Markers, Biological,
pubmed-meshheading:17492506-Up-Regulation
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
Reversal of multidrug resistance of adriamycin-resistant gastric adenocarcinoma cells through the up-regulation of DARPP-32.
|
|
pubmed:affiliation |
State Key Laboratory of Cancer Biology & Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, Shaanxi Province, China.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
