Linked Life Data

17491147

Source:http://linkedlifedata.com/resource/pubmed/id/17491147

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2007-5-11
pubmed:abstractText
The two types of cells that make up the cumulus-oocyte complex (i.e. the oocyte and cumulus cells) have very different metabolic demands, with glucose occupying a central role in metabolic activity. Cumulus cells have a significant requirement for and utilise high levels of glucose, yet appear to have little need for oxidative metabolism. In contrast, oocytes have a requirement for oxidative metabolism, although limited glucose metabolism may also be an important aspect of meiotic and developmental competence. Nevertheless, because of the metabolic and communication link between the cumulus and the oocyte, glucose availability and metabolism within the cumulus can have a significant impact on oocyte meiotic and developmental competence. In particular, the role of the hexosamine biosynthesis pathway within cumulus cells appears critical for the supply of substrate from glucose for extracellular matrix production, yet if overstimulated can significantly decrease developmental competence of the oocyte. Current static systems for in vitro maturation are clearly incompatible with meeting substrate demands, especially glucose. In the future, in vitro maturation will include a more dynamic approach, which will adjust nutrient components to meet the changing functional requirements of cumulus-oocyte complexes during the final process of maturation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:author
pubmed:volume
64
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
179-90
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Metabolism of the bovine cumulus-oocyte complex and influence on subsequent developmental competence.
pubmed:affiliation
Research Centre for Reproductive Health, School of Paediatrics and Reproductive Health, The University of Adelaide, Adelaide 5005. Jeremy.Thompson@adelaide.edu.au
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't