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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
13
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pubmed:dateCreated |
2007-6-18
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pubmed:abstractText |
The synthesis and biological activity of a novel series of thrombin receptor antagonists is described. This series of compounds showed excellent in vitro and in vivo potency. The most potent compound 40 had an IC(50) of 7.6 nM and showed robust inhibition of platelet aggregation in a cynomolgus monkey model after oral administration.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:Agans-FantuzziJacquelineJ,
pubmed-author:AhnHo-SamHS,
pubmed-author:BoykowGeorgeG,
pubmed-author:ChackalamannilSamuelS,
pubmed-author:ChintalaMadhuM,
pubmed-author:ClasbyMartin CMC,
pubmed-author:CzarnieckiMichaelM,
pubmed-author:DollerDaríoD,
pubmed-author:EagenKeithK,
pubmed-author:GreenleeWilliam JWJ,
pubmed-author:HsiehYunshengY,
pubmed-author:McPhailAndrew TAT,
pubmed-author:OrrV BVB,
pubmed-author:TagatJayaram RJR,
pubmed-author:TsaiHsinganH,
pubmed-author:YanXiaX
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3647-51
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pubmed:meshHeading |
pubmed-meshheading:17490877-Administration, Oral,
pubmed-meshheading:17490877-Alkaloids,
pubmed-meshheading:17490877-Animals,
pubmed-meshheading:17490877-Area Under Curve,
pubmed-meshheading:17490877-Chemistry, Pharmaceutical,
pubmed-meshheading:17490877-Furans,
pubmed-meshheading:17490877-Inhibitory Concentration 50,
pubmed-meshheading:17490877-Ligands,
pubmed-meshheading:17490877-Macaca fascicularis,
pubmed-meshheading:17490877-Models, Chemical,
pubmed-meshheading:17490877-Naphthalenes,
pubmed-meshheading:17490877-Parasympatholytics,
pubmed-meshheading:17490877-Piperidines,
pubmed-meshheading:17490877-Platelet Aggregation,
pubmed-meshheading:17490877-Protein Binding,
pubmed-meshheading:17490877-Rats,
pubmed-meshheading:17490877-Receptors, Thrombin,
pubmed-meshheading:17490877-Thrombin
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pubmed:year |
2007
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pubmed:articleTitle |
Himbacine derived thrombin receptor antagonists: discovery of a new tricyclic core.
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pubmed:affiliation |
Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. martin.clasby@spcorp.com <martin.clasby@spcorp.com>
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pubmed:publicationType |
Journal Article
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