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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2007-7-25
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pubmed:abstractText |
Psoriasis is a chronic inflammatory skin disease characterized by hyperproliferation and altered differentiation of keratinocytes in reply to cytokines such as interferon (IFN)-gamma and tumour necrosis factor (TNF)-alpha, provided by infiltrating CD4+ and CD8+ T cells and natural killer cells. Infliximab is a chimeric monoclonal antibody that neutralizes both soluble and membrane-bound TNF-alpha, and that may give a long-term disease remission.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0007-0963
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
157
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
249-58
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17489975-Adult,
pubmed-meshheading:17489975-Antibodies, Monoclonal,
pubmed-meshheading:17489975-Antigen Presentation,
pubmed-meshheading:17489975-Antigens, CD45,
pubmed-meshheading:17489975-Apoptosis,
pubmed-meshheading:17489975-CD4-Positive T-Lymphocytes,
pubmed-meshheading:17489975-CD8-Positive T-Lymphocytes,
pubmed-meshheading:17489975-Cell Differentiation,
pubmed-meshheading:17489975-Cells, Cultured,
pubmed-meshheading:17489975-Dendritic Cells,
pubmed-meshheading:17489975-Dose-Response Relationship, Drug,
pubmed-meshheading:17489975-Humans,
pubmed-meshheading:17489975-Interferon-gamma,
pubmed-meshheading:17489975-Interleukin-10,
pubmed-meshheading:17489975-Lymphocyte Activation,
pubmed-meshheading:17489975-Psoriasis,
pubmed-meshheading:17489975-Skin,
pubmed-meshheading:17489975-Tumor Necrosis Factor-alpha
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pubmed:year |
2007
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pubmed:articleTitle |
Antitumour necrosis factor-alpha chimeric antibody (infliximab) inhibits activation of skin-homing CD4+ and CD8+ T lymphocytes and impairs dendritic cell function.
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pubmed:affiliation |
Laboratory of Immunology and Allergology, Istituto Dermopatico dell'Immacolata, IRCCS, via dei Monti di Creta 104, 00167 Rome, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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