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rdf:type |
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lifeskim:mentions |
umls-concept:C0003316,
umls-concept:C0019630,
umls-concept:C0020792,
umls-concept:C0032659,
umls-concept:C0205314,
umls-concept:C0332183,
umls-concept:C0439064,
umls-concept:C0449450,
umls-concept:C0536940,
umls-concept:C0679622,
umls-concept:C1413787,
umls-concept:C1556094,
umls-concept:C1704858,
umls-concept:C2825965
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pubmed:issue |
7
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pubmed:dateCreated |
2007-6-4
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pubmed:abstractText |
NY-ESO-1 is a cancer-testis antigen that elicits strong cellular and humoral immune responses against NY-ESO-1-expressing tumors. Although CD4(+) T cells play a critical role in inducing antitumor immunity, little is known about MHC class II-restricted helper epitopes of the NY-ESO-1 antigen compared with MHC class I-restricted epitopes. Here, we searched for new NY-ESO-1 helper epitopes presented by MHC class II molecules, especially those found frequently in the Japanese population. We established five NY-ESO-1-specific helper T-cell lines from healthy Japanese donors using NY-ESO-1 recombinant protein and peptide. Using MHC class II-specific antibodies and a panel of Epstein-Barr virus-transformed B-cell lines, it was demonstrated that four out of the five T-cell lines recognized a region within NY-ESO-1(119-143) in the context of HLA-DRB1*0802, DRB1*0901, DRB1*1502 or DRB1*0405/*0410. In addition, using a set of overlapping 15-mer synthetic peptides, we found that NY-ESO-1(122-138) was a promiscuous region that bound to four distinct HLA-DR molecules found in the Japanese population. These findings expand the usefulness of NY-ESO-1 as a tool for tumor vaccine therapy in eliciting NY-ESO-1-specific helper T-cell responses, especially in Japanese cancer patients.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/CTAG1B protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cancer Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-D Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DR Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DRB1 Chains,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1347-9032
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
98
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1092-8
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:17488334-Amino Acid Sequence,
pubmed-meshheading:17488334-Antigens, Neoplasm,
pubmed-meshheading:17488334-Asian Continental Ancestry Group,
pubmed-meshheading:17488334-CD4-Positive T-Lymphocytes,
pubmed-meshheading:17488334-Cancer Vaccines,
pubmed-meshheading:17488334-Cell Line,
pubmed-meshheading:17488334-Cells, Cultured,
pubmed-meshheading:17488334-Dendritic Cells,
pubmed-meshheading:17488334-Epitopes,
pubmed-meshheading:17488334-HLA-D Antigens,
pubmed-meshheading:17488334-HLA-DR Antigens,
pubmed-meshheading:17488334-HLA-DRB1 Chains,
pubmed-meshheading:17488334-Humans,
pubmed-meshheading:17488334-Japan,
pubmed-meshheading:17488334-Membrane Proteins,
pubmed-meshheading:17488334-Molecular Sequence Data,
pubmed-meshheading:17488334-Neoplasms,
pubmed-meshheading:17488334-Peptide Fragments,
pubmed-meshheading:17488334-T-Lymphocytes
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pubmed:year |
2007
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pubmed:articleTitle |
Identification of a novel NY-ESO-1 promiscuous helper epitope presented by multiple MHC class II molecules found frequently in the Japanese population.
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pubmed:affiliation |
Division of Immunoregulation, Section of Disease Control, Hokkaido University, Sapporo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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