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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2007-6-12
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pubmed:abstractText |
Tumour regression requires activation of T cells. It has been shown that the interaction between T cell-expressed CD40-ligand (CD40-L) and antigen-presenting cell-expressed CD40 plays a crucial role in T cell activation. CD40-L- or CD40-deficient mice are susceptible to tumour growth. CD40-based therapies are also shown to control tumour growth significantly, suggesting that CD40-CD40-L interaction induces anti-tumour T cell responses and tumour regression. We demonstrate that the anti-tumour T cell response can be modulated reciprocally as a function of the levels of CD40 expression. At low expression levels, CD40 promotes tumour growth; at higher expression levels, CD40 induces tumour-regressing T cell response. Dendritic cells (DC) sorted onto major histocompatibility complex (MHC)-II expression are found to be similar in CD40 and CD80 expression. The MHC-II(hi)/CD40(hi) DC induce interleukin (IL)-12-dominated and T helper 1 (Th1)-type response, whereas MHC-II(lo)/CD40(lo) DC promote high IL-10 and Th2-type T cells. The T cells induced by these DC also differ in terms of regulatory T cell markers, lymphocyte activation gene-3 (LAG-3) and glucocorticoid-induced tumour necrosis factor (TNF) receptor family-related gene (GITR). Thus, we report for the first time that CD40-induced effector T cell response depends on CD40 expression levels in vivo.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17488293-10452994,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17488293-10910069,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17488293-11526222,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17488293-11606395,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17488293-11929985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17488293-12209589,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17488293-12471116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17488293-12732656,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17488293-12893749,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17488293-15001471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17488293-15107845,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17488293-15315967,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17488293-15528325,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17488293-15665830,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17488293-15868592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17488293-17082576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17488293-7514045,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17488293-8620513,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17488293-8760829,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17488293-8958922,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17488293-9544571
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
149
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
194-202
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17488293-Animals,
pubmed-meshheading:17488293-Antigens, CD40,
pubmed-meshheading:17488293-B-Lymphocytes,
pubmed-meshheading:17488293-Cell Division,
pubmed-meshheading:17488293-Cytotoxicity, Immunologic,
pubmed-meshheading:17488293-Dendritic Cells,
pubmed-meshheading:17488293-Immunoglobulin G,
pubmed-meshheading:17488293-Immunoglobulin M,
pubmed-meshheading:17488293-Interferon-gamma,
pubmed-meshheading:17488293-Interleukin-10,
pubmed-meshheading:17488293-Liver Neoplasms, Experimental,
pubmed-meshheading:17488293-Mice,
pubmed-meshheading:17488293-Mice, Inbred BALB C,
pubmed-meshheading:17488293-Neoplasm Transplantation,
pubmed-meshheading:17488293-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17488293-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:17488293-Tumor Cells, Cultured
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pubmed:year |
2007
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pubmed:articleTitle |
Levels of CD40 expression on dendritic cells dictate tumour growth or regression.
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pubmed:affiliation |
National Centre for Cell Science, Ganeshkhind, Pune, India.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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