Linked Life Data

17487900

Source:http://linkedlifedata.com/resource/pubmed/id/17487900

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2007-7-3
pubmed:abstractText
The in silico design, synthesis, and biological evaluation of ten potent type II dehydroquinase inhibitors are described. These compounds contain an anhydroquinate core, incorporated as a mimic of the enolate reaction intermediate. This substructure is attached by a variety of linking units to a terminal phenyl group that binds in an adjacent pocket. Inhibitors were synthesised from (-)-quinic acid using palladium-catalysed Stille and carboamidation chemistry. Several inhibitors exhibited nanomolar inhibition constants against type II dehydroquinases from Streptomyces coelicolor and Mycobacterium tuberculosis. These are among the most potent inhibitors of these enzymes reported to date.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1860-7187
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1015-29
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Rational design, synthesis, and evaluation of nanomolar type II dehydroquinase inhibitors.
pubmed:affiliation
Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't