| pubmed-article:17487386 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17487386 | lifeskim:mentions | umls-concept:C0388911 | lld:lifeskim |
| pubmed-article:17487386 | lifeskim:mentions | umls-concept:C0007113 | lld:lifeskim |
| pubmed-article:17487386 | lifeskim:mentions | umls-concept:C0034897 | lld:lifeskim |
| pubmed-article:17487386 | lifeskim:mentions | umls-concept:C0205276 | lld:lifeskim |
| pubmed-article:17487386 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:17487386 | lifeskim:mentions | umls-concept:C1514307 | lld:lifeskim |
| pubmed-article:17487386 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:17487386 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:17487386 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:17487386 | pubmed:dateCreated | 2007-5-9 | lld:pubmed |
| pubmed-article:17487386 | pubmed:abstractText | Vascular endothelial growth factor-C (VEGF-C) is considered to be a specific factor promoting lymphangiogenesis. There have been reports of a positive correlation between local recurrence of rectal carcinoma and lymphatic invasion by the tumor. The aim of this study was to determine the clinical significance of VEGF-C expression for identifying lymphangiogenesis as a predictor of the local recurrence of rectal carcinoma. One hundred surgical specimens of rectal carcinoma from patients with (n=26) or without (n=74) local recurrence were studied. VEGF-C protein expression was assessed immunohistochemically. The correlations between VEGF-C expression, various clinicopathologic factors, the microscopic lymphatic vessel density (MLVD), and lymphatic invasion were studied. The MLVD (determined by immunohistostaining for D2-40) was significantly higher in VEGF-C positive tumors than VEGF-C negative tumors. VEGF-C positivity was only correlated with lymphatic involvement. Moreover, multivariate analysis showed that VEGF-C protein expression was an independent risk factor for the local recurrence of rectal carcinoma, and patients with VEGF-C positive tumors had a significantly worse prognosis than those with VEGF-C negative tumors. Expression of VEGF-C may be a good predictor of the local recurrence of rectal carcinoma and may also be a useful prognostic indicator. | lld:pubmed |
| pubmed-article:17487386 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17487386 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17487386 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17487386 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17487386 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17487386 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17487386 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:17487386 | pubmed:issn | 1021-335X | lld:pubmed |
| pubmed-article:17487386 | pubmed:author | pubmed-author:MaedaKiyoshiK | lld:pubmed |
| pubmed-article:17487386 | pubmed:author | pubmed-author:NishiguchiYuk... | lld:pubmed |
| pubmed-article:17487386 | pubmed:author | pubmed-author:OhiraMasaichi... | lld:pubmed |
| pubmed-article:17487386 | pubmed:author | pubmed-author:HirakawaKosei... | lld:pubmed |
| pubmed-article:17487386 | pubmed:author | pubmed-author:InoueToruT | lld:pubmed |
| pubmed-article:17487386 | pubmed:author | pubmed-author:NishiharaTama... | lld:pubmed |
| pubmed-article:17487386 | pubmed:author | pubmed-author:NodaEijiE | lld:pubmed |
| pubmed-article:17487386 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17487386 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:17487386 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17487386 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17487386 | pubmed:pagination | 1327-31 | lld:pubmed |
| pubmed-article:17487386 | pubmed:meshHeading | pubmed-meshheading:17487386... | lld:pubmed |
| pubmed-article:17487386 | pubmed:meshHeading | pubmed-meshheading:17487386... | lld:pubmed |
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| pubmed-article:17487386 | pubmed:meshHeading | pubmed-meshheading:17487386... | lld:pubmed |
| pubmed-article:17487386 | pubmed:meshHeading | pubmed-meshheading:17487386... | lld:pubmed |
| pubmed-article:17487386 | pubmed:meshHeading | pubmed-meshheading:17487386... | lld:pubmed |
| pubmed-article:17487386 | pubmed:meshHeading | pubmed-meshheading:17487386... | lld:pubmed |
| pubmed-article:17487386 | pubmed:meshHeading | pubmed-meshheading:17487386... | lld:pubmed |
| pubmed-article:17487386 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17487386 | pubmed:articleTitle | Predictive value of vascular endothelial growth factor-C expression for local recurrence of rectal carcinoma. | lld:pubmed |
| pubmed-article:17487386 | pubmed:affiliation | Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan. nodatch@med.osaka-cu.ac.jp | lld:pubmed |
| pubmed-article:17487386 | pubmed:publicationType | Journal Article | lld:pubmed |
