Linked Life Data

17487386

Source:http://linkedlifedata.com/resource/pubmed/id/17487386

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2007-5-9
pubmed:abstractText
Vascular endothelial growth factor-C (VEGF-C) is considered to be a specific factor promoting lymphangiogenesis. There have been reports of a positive correlation between local recurrence of rectal carcinoma and lymphatic invasion by the tumor. The aim of this study was to determine the clinical significance of VEGF-C expression for identifying lymphangiogenesis as a predictor of the local recurrence of rectal carcinoma. One hundred surgical specimens of rectal carcinoma from patients with (n=26) or without (n=74) local recurrence were studied. VEGF-C protein expression was assessed immunohistochemically. The correlations between VEGF-C expression, various clinicopathologic factors, the microscopic lymphatic vessel density (MLVD), and lymphatic invasion were studied. The MLVD (determined by immunohistostaining for D2-40) was significantly higher in VEGF-C positive tumors than VEGF-C negative tumors. VEGF-C positivity was only correlated with lymphatic involvement. Moreover, multivariate analysis showed that VEGF-C protein expression was an independent risk factor for the local recurrence of rectal carcinoma, and patients with VEGF-C positive tumors had a significantly worse prognosis than those with VEGF-C negative tumors. Expression of VEGF-C may be a good predictor of the local recurrence of rectal carcinoma and may also be a useful prognostic indicator.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1021-335X
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1327-31
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Predictive value of vascular endothelial growth factor-C expression for local recurrence of rectal carcinoma.
pubmed:affiliation
Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan. nodatch@med.osaka-cu.ac.jp
pubmed:publicationType
Journal Article