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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
35
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pubmed:dateCreated |
1992-1-17
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pubmed:abstractText |
The lipopeptidophosphoglycan is the major cell surface glycoconjugate of the epimastigote forms of the parasitic protozoan Trypanosoma cruzi. A detailed partial structure for this molecule has been reported (Previato, J. O., Gorin, P. A. J., Mazurek, M., Xavier, M. T., Fournet, B., Wieruszesk, J. M., and Mendonca-Previato, L. (1990) J. Biol. Chem. 265, 2518-2526). In this study, we complete the primary structure assignments and describe the microheterogeneity found in the lipopeptidophosphoglycan glycan, using a combination of 1H and 31P NMR, fast atom bombardment mass spectrometry, methylation linkage analysis, and exoglycosidase sequencing. The lipopeptidophosphoglycan is a glycosylated inositol-phosphoceramide with striking homology to glycosylphosphatidylinositol membrane anchors found attached to a wide variety of plasma membrane proteins throughout the eukaryotes.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0021-9258
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
15
|
pubmed:volume |
266
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
23670-5
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pubmed:dateRevised |
2010-8-25
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pubmed:meshHeading |
pubmed-meshheading:1748644-Acylation,
pubmed-meshheading:1748644-Animals,
pubmed-meshheading:1748644-Carbohydrate Sequence,
pubmed-meshheading:1748644-Chromatography, High Pressure Liquid,
pubmed-meshheading:1748644-Magnetic Resonance Spectroscopy,
pubmed-meshheading:1748644-Molecular Sequence Data,
pubmed-meshheading:1748644-Oligosaccharides,
pubmed-meshheading:1748644-Peptidoglycan,
pubmed-meshheading:1748644-Phospholipids,
pubmed-meshheading:1748644-Spectrometry, Mass, Fast Atom Bombardment,
pubmed-meshheading:1748644-Trypanosoma cruzi
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pubmed:year |
1991
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pubmed:articleTitle |
Complete structure of the glycan of lipopeptidophosphoglycan from Trypanosoma cruzi Epimastigotes.
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pubmed:affiliation |
Departamento de Quimica Organica, Facultad de Ciencas Exactas y Naturales, Universidad de Buenos Aires, Argentina.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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