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rdf:type |
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lifeskim:mentions |
umls-concept:C0001807,
umls-concept:C0032520,
umls-concept:C0205250,
umls-concept:C0206743,
umls-concept:C0332257,
umls-concept:C0392762,
umls-concept:C0596611,
umls-concept:C0812273,
umls-concept:C1513380,
umls-concept:C1514811,
umls-concept:C1561577,
umls-concept:C1704461,
umls-concept:C1706462
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|
pubmed:issue |
11
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pubmed:dateCreated |
2007-9-10
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pubmed:abstractText |
SMARCB1/INI1, which negatively regulates cell cycle progression from G0/G1 into the S-phase via the p16INK4a-RB-E2F pathway, has been reported to be inactivated homozygously by deletion and/or mutations in malignant rhabdoid tumor (MRT). In the current study, we investigated the alteration of the SMARCB1/INI1 gene using simple methods, and its gene product at the protein level. Moreover, we investigated the status of hyperphosphorylation in RB protein, known as a key cell cycle molecule.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0171-5216
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
133
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
817-24
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pubmed:meshHeading |
pubmed-meshheading:17486366-Child, Preschool,
pubmed-meshheading:17486366-Chromosomal Proteins, Non-Histone,
pubmed-meshheading:17486366-DNA-Binding Proteins,
pubmed-meshheading:17486366-Female,
pubmed-meshheading:17486366-Gene Deletion,
pubmed-meshheading:17486366-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:17486366-Humans,
pubmed-meshheading:17486366-Immunoenzyme Techniques,
pubmed-meshheading:17486366-Infant,
pubmed-meshheading:17486366-Infant, Newborn,
pubmed-meshheading:17486366-Male,
pubmed-meshheading:17486366-Mutation,
pubmed-meshheading:17486366-Phosphorylation,
pubmed-meshheading:17486366-Retinoblastoma Protein,
pubmed-meshheading:17486366-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17486366-Rhabdoid Tumor,
pubmed-meshheading:17486366-Transcription Factors
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pubmed:year |
2007
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pubmed:articleTitle |
Highly aggressive behavior of malignant rhabdoid tumor: a special reference to SMARCB1/INI1 gene alterations using molecular genetic analysis including quantitative real-time PCR.
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pubmed:affiliation |
Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, 812-8582, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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