Linked Life Data

17485274

Source:http://linkedlifedata.com/resource/pubmed/id/17485274

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2007-5-8
pubmed:abstractText
Fabricated solid-state nanopore chips are used to probe individual single stranded DNA (ssDNA) homopolymers. Based on the analysis of the current blockage caused by DNA translocation through a voltage-biased nanopore, we discovered that the hydrodynamic diameter of ssDNA homopolymer helix is comparable to that of double stranded DNA (dsDNA) helix. This proof-of-principle demonstration shows that solid-state nanopore technology can be used to spy on secondary structures of biopolymers. We also show that ssDNA manifests slower and distinct translocation kinetics in comparison to dsDNA. Furthermore, the present study helps to refine our understanding of the ssDNA translocation kinetics through narrower alpha-hemolysin protein pores.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1093-4715
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2978-83
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Detecting translocation of individual single stranded DNA homopolymers through a fabricated nanopore chip.
pubmed:affiliation
Samsung Advanced Institute of Technology, South Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't